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Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17)

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CD269; BCM; BCMA; B-cell maturation protein

Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17)
CCC A790
HGNC 11913
MGI 1343050
PubMed 20016944
RGD 1304703
UniProt Q02223
Wiki 22108903

Tumor necrosis factor receptor superfamily member 17 is  a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b, and to lead to NF-kappaB and MAPK8/JNK activation.

This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.The patient from whose tumor cells the 4;16 translocation was derived had a chronic intestinal malabsorption syndrome. Histologic and immunohistochemical studies demonstrated a lymphoproliferative syndrome of mature T cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins APA790Hu01 Active Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Cell culture; Activity Assays.
RPA790Hu01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Polyclonal Antibody Customized Service Offer
Assay Kits SEA790Hu ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA790Mu01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Positive Control; Immunogen; SDS-PAGE; WB.
RPA790Mu02 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA790Mu01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IP.
LAA790Mu71 Biotin-Linked Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC.
PAA790Mu02 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IP.
Assay Kits SEA790Mu ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) ELISA Kit Customized Service Offer
  1. "A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma."EMBO J. 11:3897-3904(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed."Nucleic Acids Res. 22:1147-1154(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Presence of four major haplotypes in human BCMA gene: lack of association with systemic lupus erythematosus and rheumatoid arthritis."Genes Immun. 2:276-279(2001) [PubMed] [Europe PMC] [Abstract]
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  6. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  7. "TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase."J. Immunol. 165:1322-1330(2000) [PubMed] [Europe PMC] [Abstract]
  8. "TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease."Nature 404:995-999(2000) [PubMed] [Europe PMC] [Abstract]
  9. "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity."Nat. Immunol. 1:252-256(2000) [PubMed] [Europe PMC] [Abstract]
  10. "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1."Proc. Natl. Acad. Sci. U.S.A. 97:9156-9161(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Ligand-receptor binding revealed by the TNF family member TALL-1."Nature 423:49-56(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding."J. Biol. Chem. 280:7218-7227(2005) [PubMed] [Europe PMC] [Abstract]