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Osteonectin (ON)

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SPARC; BM-40; Secreted Protein,Acidic,Cysteine-Rich; Basement-membrane protein 40; Secreted protein acidic and rich in cysteine

Osteonectin (ON)
CCC A791
HGNC 11219
MGI 98373
PubMed 7034958
RGD 3742
UniProt P09486
Wiki Osteonectin

Osteonectin is a glycoprotein in the bone that binds calcium. It is secreted by osteoblasts during bone formation, initiating mineralization and promoting mineral crystal formation. Osteonectin also shows affinity for collagen in addition to bone mineral calcium. Some current research shows a correlation between osteonectin over expression and ampullary cancers and chronic pancreatitis. Osteonectin is an acidic, secreted extracellular matrix glycoprotein that plays a vital role in bone mineralization, cell-matrix interactions, and collagen binding. Osteonectin also increases the production and activity of matrix metalloproteinases, a function important to invading cancer cells within bone. Additional functions of osteonectin beneficial to tumor cells include angiogenesis, proliferation and migration.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA791Hu01 Recombinant Osteonectin (ON) Positive Control; Immunogen; SDS-PAGE; WB.
CPA791Hu21 OVA Conjugated Osteonectin (ON) Immunogen; SDS-PAGE; WB.
APA791Hu01 Active Osteonectin (ON) Cell culture; Activity Assays.
EPA791Hu61 Eukaryotic Osteonectin (ON) Positive Control; Immunogen; SDS-PAGE; WB.
APA791Hu61 Active Osteonectin (ON) Cell culture; Activity Assays.
Antibodies MAA791Hu22 Monoclonal Antibody to Osteonectin (ON) WB; IHC; ICC; IP.
LAA791Hu71 Biotin-Linked Polyclonal Antibody to Osteonectin (ON) WB; IHC; ICC.
LAA791Hu81 FITC-Linked Polyclonal Antibody to Osteonectin (ON) WB; IHC; ICC; IF.
PAA791Hu01 Polyclonal Antibody to Osteonectin (ON) WB; IHC; ICC; IP.
PAA791Hu08 Polyclonal Antibody to Osteonectin (ON) WB; IHC; ICC; IP.
Assay Kits SEA791Hu ELISA Kit for Osteonectin (ON) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA791Mu01 Recombinant Osteonectin (ON) Positive Control; Immunogen; SDS-PAGE; WB.
RPA791Mu02 Recombinant Osteonectin (ON) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA791Mu01 Polyclonal Antibody to Osteonectin (ON) WB; IHC; ICC; IP.
LAA791Mu71 Biotin-Linked Polyclonal Antibody to Osteonectin (ON) WB; IHC; ICC.
LAA791Mu81 FITC-Linked Polyclonal Antibody to Osteonectin (ON) WB; IHC; ICC; IF.
PAA791Mu02 Polyclonal Antibody to Osteonectin (ON) WB; IHC; ICC; IP.
Assay Kits SEA791Mu ELISA Kit for Osteonectin (ON) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA791Ra01 Recombinant Osteonectin (ON) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA791Ra01 Polyclonal Antibody to Osteonectin (ON) WB; IHC; ICC; IP.
LAA791Ra71 Biotin-Linked Polyclonal Antibody to Osteonectin (ON) WB; IHC; ICC.
LAA791Ra81 FITC-Linked Polyclonal Antibody to Osteonectin (ON) WB; IHC; ICC; IF.
MAA791Ra21 Monoclonal Antibody to Osteonectin (ON) WB; IHC; ICC; IP.
Assay Kits SEA791Ra ELISA Kit for Osteonectin (ON) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA791Rb01 Recombinant Osteonectin (ON) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA791Rb51 Polyclonal Antibody to Osteonectin (ON) WB; IHC; ICC; IP.
PAA791Rb01 Polyclonal Antibody to Osteonectin (ON) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Osteonectin (ON) CLIA Kit Customized Service Offer
n/a ELISA Kit for Osteonectin (ON) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Osteonectin (ON) Recombinant Protein Customized Service Offer
Antibodies PAA791Po01 Polyclonal Antibody to Osteonectin (ON) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Osteonectin (ON) CLIA Kit Customized Service Offer
n/a ELISA Kit for Osteonectin (ON) ELISA Kit Customized Service Offer
  1. "Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin)."FEBS Lett. 236:352-356(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: sequence, expression, and localization of the gene to chromosome 5q31-q33."Genomics 2:37-47(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Structure of human osteonectin based upon analysis of cDNA and genomic sequences."Biochemistry 28:6483-6491(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Structure and expression of osteonectin mRNA in human tissue."Connect. Tissue Res. 24:17-28(1990) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone."J. Biol. Chem. 262:9702-9708(1987) [PubMed] [Europe PMC] [Abstract]
  8. "Human platelet osteonectin: release, surface expression, and partial characterization."Blood 75:1105-1113(1990) [PubMed] [Europe PMC] [Abstract]
  9. "Osteonectin/SPARC/BM-40 in human decidua and carcinoma, tissues characterized by de novo formation of basement membrane."Am. J. Pathol. 132:345-355(1988) [PubMed] [Europe PMC] [Abstract]
  10. "Immunolocalization of SPARC, tenascin, and thrombospondin in pulmonary fibrosis."Am. J. Pathol. 147:1759-1769(1995) [PubMed] [Europe PMC] [Abstract]
  11. "BM-40 (osteonectin, SPARC) is expressed both in the epidermal and in the dermal compartment of adult human skin."J. Invest. Dermatol. 110:122-126(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Structure of a novel extracellular Ca(2+)-binding module in BM-40."Nat. Struct. Biol. 3:67-73(1996) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40."EMBO J. 16:3778-3786(1997) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM-40/SPARC/osteonectin."EMBO J. 17:1625-1634(1998) [PubMed] [Europe PMC] [Abstract]