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The protein encoded by this gene is a member of the TGF-β superfamily. Like other members of the bone morphogenetic protein family of proteins, it plays a key role in the transformation of mesenchymal cells into bone and cartilage. It is inhibited by noggin and a similar protein, chordin, which are expressed in the Spemann-Mangold Organizer. BMP7 may be involved in bone homeostasis. It is expressed in the brain, kidneys and bladder.
BMP7 has been discovered to be crucial in the determination of ventral-dorsal organization in zebrafish. BMP7 causes the expression of ventral phenotypes while its complete inhibition creates a dorsal phenotype. Moreover, BMP7 is eventually partially "turned off" in embryonic development in order to create the dorsal parts of the organism.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA799Mu01 | Recombinant Bone Morphogenetic Protein 7 (BMP7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA799Mu02 | Recombinant Bone Morphogenetic Protein 7 (BMP7) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA799Mu01 | Active Bone Morphogenetic Protein 7 (BMP7) | Cell culture; Activity Assays. | |
| Antibodies | PAA799Mu01 | Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IP. |
| LAA799Mu71 | Biotin-Linked Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC. | |
| PAA799Mu02 | Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IP. | |
| MAA799Mu21 | Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IP. | |
| LAA799Mu72 | Biotin-Linked Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC. | |
| Assay Kits | SEA799Mu | ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA799Ra01 | Recombinant Bone Morphogenetic Protein 7 (BMP7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA799Ra01 | Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IP. |
| MAA799Ra21 | Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IP. | |
| LAA799Ra72 | Biotin-Linked Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC. | |
| Assay Kits | SEA799Ra | ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA799Rb01 | Recombinant Bone Morphogenetic Protein 7 (BMP7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | n/a | Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Bone Morphogenetic Protein 7 (BMP7) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) | ELISA Kit Customized Service Offer |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA799Bo01 | Recombinant Bone Morphogenetic Protein 7 (BMP7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA799Bo01 | Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Bone Morphogenetic Protein 7 (BMP7) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) | ELISA Kit Customized Service Offer |
Organism species: Ovis aries; Ovine (Sheep)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Bone Morphogenetic Protein 7 (BMP7) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEA799Ov | ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) | Enzyme-linked immunosorbent assay for Antigen Detection. |
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- "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
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- "USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney."Biochem. Biophys. Res. Commun. 316:490-500(2004) [PubMed] [Europe PMC] [Abstract]
- "Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular, brain, ear, palate, and skeletal anomalies."Hum. Mutat. 31:781-787(2010) [PubMed] [Europe PMC] [Abstract]
- "Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily."Proc. Natl. Acad. Sci. U.S.A. 93:878-883(1996) [PubMed] [Europe PMC] [Abstract]