≡

Haptoglobin (Hpt)

[Edit]

HP; Hp2-Alpha; Alpha-2-Macroglobulin; Zonulin

Haptoglobin (Hpt)
CCC A817
HGNC 5141
MGI 96211
PubMed 15274115
RGD 2825
UniProt P00738
Wiki Haptoglobin

Haptoglobin is a protein that in humans is encoded by the HP gene. In blood plasma, haptoglobin binds free hemoglobin (Hb) released from erythrocytes with high affinity and thereby inhibits its oxidative activity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). In clinical settings, the haptoglobin assay is used to screen for and monitor intravascular hemolytic anemia. In intravascular hemolysis free hemoglobin will be released into circulation and hence haptoglobulin will bind the Hb. This causes a decline in Hp levels. Conversely, in extravascular hemolysis the reticuloendothelial system, especially splenic monocytes, phagocytose the erythrocytes and hemoglobin is not released into circulation and hence haptoglobulin levels are normal.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA817Hu01 Recombinant Haptoglobin (Hpt) Positive Control; Immunogen; SDS-PAGE; WB.
RPA817Hu02 Recombinant Haptoglobin (Hpt) Positive Control; Immunogen; SDS-PAGE; WB.
RPA817Hu03 Recombinant Haptoglobin (Hpt) Positive Control; Immunogen; SDS-PAGE; WB.
RPA817Hu04 Recombinant Haptoglobin (Hpt) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA817Hu01 Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
MAA817Hu22 Monoclonal Antibody to Haptoglobin (Hpt) WB; IHC
PAA817Hu02 Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC
LAA817Hu71 Biotin-Linked Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC.
LAA817Hu72 Biotin-Linked Monoclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC.
MAA817Hu21 Monoclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
MAA817Hu23 Monoclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
MAA817Hu24 Monoclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
MAA817Hu25 Monoclonal Antibody to Haptoglobin (Hpt) WB; IHC
MAA817Hu27 Monoclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
PAA817Hu03 Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
PAA817Hu04 Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
MAA817Hu29 Monoclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
MAA817Hu28 Monoclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
MAA817Hu26 Monoclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
Assay Kits SEA817Hu ELISA Kit for Haptoglobin (Hpt) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA817Hu CLIA Kit for Haptoglobin (Hpt) Chemiluminescent immunoassay for Antigen Detection.
HEA817Hu High Sensitive ELISA Kit for Haptoglobin (Hpt) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA817Mu01 Recombinant Haptoglobin (Hpt) Positive Control; Immunogen; SDS-PAGE; WB.
RPA817Mu02 Recombinant Haptoglobin (Hpt) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA817Mu01 Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
LAA817Mu71 Biotin-Linked Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC.
PAA817Mu02 Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
Assay Kits SEA817Mu ELISA Kit for Haptoglobin (Hpt) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA817Ra01 Recombinant Haptoglobin (Hpt) Positive Control; Immunogen; SDS-PAGE; WB.
RPA817Ra03 Recombinant Haptoglobin (Hpt) Positive Control; Immunogen; SDS-PAGE; WB.
RPA817Ra02 Recombinant Haptoglobin (Hpt) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA817Ra01 Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
LAA817Ra71 Biotin-Linked Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC.
MAA817Ra21 Monoclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
PAA817Ra03 Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
PAA817Ra02 Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
Assay Kits SEA817Ra ELISA Kit for Haptoglobin (Hpt) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA817Rb02 Recombinant Haptoglobin (Hpt) Positive Control; Immunogen; SDS-PAGE; WB.
RPA817Rb01 Recombinant Haptoglobin (Hpt) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA817Rb53 Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
PAA817Rb51 Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
PAA817Rb52 Polyclonal Antibody to Haptoglobin (Hpt) WB,IHC
LAA817Rb71 Biotin-Linked Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC.
PAA817Rb01 Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
PAA817Rb02 Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
Assay Kits SEA817Rb ELISA Kit for Haptoglobin (Hpt) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA817Ca01 Recombinant Haptoglobin (Hpt) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA817Ca01 Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
MAA817Ca21 Monoclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
Assay Kits SEA817Ca ELISA Kit for Haptoglobin (Hpt) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA817Po01 Recombinant Haptoglobin (Hpt) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA817Po01 Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
LAA817Po71 Biotin-Linked Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC.
MAA817Po21 Monoclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
Assay Kits SEA817Po ELISA Kit for Haptoglobin (Hpt) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA817Bo01 Recombinant Haptoglobin (Hpt) Positive Control; Immunogen; SDS-PAGE; WB.
RPA817Bo02 Recombinant Haptoglobin (Hpt) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA817Bo01 Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
MAA817Bo21 Monoclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
PAA817Bo02 Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
Assay Kits SEA817Bo ELISA Kit for Haptoglobin (Hpt) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA817Cp01 Recombinant Haptoglobin (Hpt) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA817Cp01 Polyclonal Antibody to Haptoglobin (Hpt) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Haptoglobin (Hpt) CLIA Kit Customized Service Offer
n/a ELISA Kit for Haptoglobin (Hpt) ELISA Kit Customized Service Offer
  1. "Molecular cloning of human haptoglobin cDNA: evidence for a single mRNA coding for alpha 2 and beta chains."EMBO J. 2:1003-1007(1983) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of human haptoglobin cDNA."Proc. Natl. Acad. Sci. U.S.A. 80:5875-5879(1983) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of human haptoglobin cDNAs coding for alpha 2FS beta and alpha 1S beta variants."FEBS Lett. 168:103-107(1984) [PubMed] [Europe PMC] [Abstract]
  4. "Evolution of haptoglobin: comparison of complementary DNA encoding Hp alpha 1S and Hp alpha 2FS."Nucleic Acids Res. 12:4531-4538(1984) [PubMed] [Europe PMC] [Abstract]
  5. "Structure and expression of the human haptoglobin locus."EMBO J. 4:119-126(1985) [PubMed] [Europe PMC] [Abstract]
  6. "Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element."J. Biol. Chem. 260:6698-6709(1985) [PubMed] [Europe PMC] [Abstract]
  7. "Junctions between genes in the haptoglobin gene cluster of primates."Genomics 14:948-958(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Expression of cloned human haptoglobin and alpha 1-antitrypsin complementary DNAs in Saccharomyces cerevisiae."DNA 5:129-136(1986) [PubMed] [Europe PMC] [Abstract]
  12. "Sequence of human haptoglobin cDNA: evidence that the alpha and beta subunits are coded by the same mRNA."Nucleic Acids Res. 11:5811-5819(1983) [PubMed] [Europe PMC] [Abstract]
  13. "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Duplication within the haptoglobin Hp2 gene."Nature 309:131-135(1984) [PubMed] [Europe PMC] [Abstract]
  15. "Covalent structure of human haptoglobin: a serine protease homolog."Proc. Natl. Acad. Sci. U.S.A. 77:3388-3392(1980) [PubMed] [Europe PMC] [Abstract]
  16. "Protein analysis of human maculae in relation to age-related maculopathy."Lab. Invest. 73:267-272(1995) [PubMed] [Europe PMC] [Abstract]
  17. "Studies on the interchain disulfides of human haptoglobins."Can. J. Biochem. 51:249-264(1973) [PubMed] [Europe PMC] [Abstract]
  18. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
  22. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  23. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Enrichment of glycopeptides for glycan structure and attachment site identification."Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2."Proc. Natl. Acad. Sci. U.S.A. 106:16799-16804(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Haptoglobin: basic and clinical aspects."Antioxid. Redox Signal. 12:293-304(2010) [PubMed] [Europe PMC] [Abstract]
  27. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  28. "Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer."Physiol. Rev. 91:151-175(2011) [PubMed] [Europe PMC] [Abstract]
  29. "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
  30. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  31. "A novel I247T missense mutation in the haptoglobin 2 beta-chain decreases the expression of the protein and is associated with ahaptoglobinemia."Hum. Genet. 114:499-502(2004) [PubMed] [Europe PMC] [Abstract]