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Protease Activated Receptor 3 (PAR3)

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F2-RL2; F2RL2; PAR3; Coagulation Factor II(thrombin)receptor-Like 2

Protease Activated Receptor 3 (PAR3)
CCC A826
HGNC 3539
MGI 1298208
PubMed 15723052
RGD 620871
UniProt O00254
Wiki PAR3

Protease activated receptor 3 (PAR3), is aprotein encoded by the F2RL2 .Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane receptors that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor.

F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protease Activated Receptor 3 (PAR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protease Activated Receptor 3 (PAR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protease Activated Receptor 3 (PAR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protease Activated Receptor 3 (PAR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protease Activated Receptor 3 (PAR3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protease Activated Receptor 3 (PAR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protease Activated Receptor 3 (PAR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protease Activated Receptor 3 (PAR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protease Activated Receptor 3 (PAR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protease Activated Receptor 3 (PAR3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protease Activated Receptor 3 (PAR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protease Activated Receptor 3 (PAR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protease Activated Receptor 3 (PAR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protease Activated Receptor 3 (PAR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protease Activated Receptor 3 (PAR3) ELISA Kit Customized Service Offer
  1. "Protease-activated receptor 3 is a second thrombin receptor in humans."Nature 386:502-506(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a PAR gene cluster and characterization in vascular endothelial cells and platelets."J. Biol. Chem. 273:15061-15068(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin."J. Clin. Invest. 103:879-887(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3."Biochem. Biophys. Res. Commun. 341:1001-1006(2006) [PubMed] [Europe PMC] [Abstract]