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Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18)

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AITRL; GITRL; TL6; hGITRL; Activation-Inducible Tumor Necrosis Factor Receptor Ligand; Glucocorticoid-induced TNF-related ligand

Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18)
CCC A844
HGNC 11932
MGI 2673064
PubMed 17963343
RGD 1305066
UniProt Q9UNG2
Wiki TNFRSF18

Tumor necrosis factor ligand superfamily member 18 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.

By screening a panel of epitope-tagged candidate TNF ligand proteins for binding to a recombinant AITR protein, these authors identified the AITR ligand, AITRL or TL6. Northern blot analysis revealed that TL6 is expressed as a 2.4-kb mRNA in pancreas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins EPA844Hu61 Eukaryotic Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) Positive Control; Immunogen; SDS-PAGE; WB.
APA844Hu01 Active Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) Cell culture; Activity Assays.
APA844Hu61 Active Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) ELISA Kit Customized Service Offer
  1. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
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  7. "Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells."J. Leukoc. Biol. 82:93-105(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion."J. Pharmacol. Exp. Ther. 347:164-172(2013) [PubMed] [Europe PMC] [Abstract]
  9. "Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: implications for function."Proc. Natl. Acad. Sci. U.S.A. 104:19452-19457(2007) [PubMed] [Europe PMC] [Abstract]