Glycogen Phosphorylase, Liver (PYGL)
[Edit]GPLL; GPBB; Hers Disease; Glycogen Storage Disease Type VI
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PYGL is a homodimeric protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15.
Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, or Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA849Hu01 | Recombinant Glycogen Phosphorylase, Liver (PYGL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA849Hu02 | Recombinant Glycogen Phosphorylase, Liver (PYGL) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA849Hu01 | Polyclonal Antibody to Glycogen Phosphorylase, Liver (PYGL) | WB; IHC; ICC; IP. |
| MAA849Hu22 | Monoclonal Antibody to Glycogen Phosphorylase, Liver (PYGL) | WB; IHC; ICC; IP. | |
| PAA849Hu02 | Polyclonal Antibody to Glycogen Phosphorylase, Liver (PYGL) | WB,IHC | |
| LAA849Hu71 | Biotin-Linked Polyclonal Antibody to Glycogen Phosphorylase, Liver (PYGL) | WB; IHC; ICC. | |
| Assay Kits | SEA849Hu | ELISA Kit for Glycogen Phosphorylase, Liver (PYGL) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA849Mu01 | Recombinant Glycogen Phosphorylase, Liver (PYGL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA849Mu02 | Recombinant Glycogen Phosphorylase, Liver (PYGL) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA849Mu01 | Polyclonal Antibody to Glycogen Phosphorylase, Liver (PYGL) | WB; IHC; ICC; IP. |
| PAA849Mu02 | Polyclonal Antibody to Glycogen Phosphorylase, Liver (PYGL) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA849Mu | ELISA Kit for Glycogen Phosphorylase, Liver (PYGL) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
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