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Caspase 8 (CASP8)

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CAP4; FLICE; MACH; MCH5; Cysteinyl Aspartate Specific Proteinases 8; Apoptotic cysteine protease; FADD-homologous ICE/ced-3-like protease; MORT1-associated ced-3 homolog

Caspase 8 (CASP8)
CCC A853
HGNC 1509
MGI 1261423
PubMed 11185963
RGD 620945
UniProt Q14790
Wiki Caspase_8

Caspase 8 is a member caspase family. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA853Hu01 Recombinant Caspase 8 (CASP8) Positive Control; Immunogen; SDS-PAGE; WB.
RPA853Hu02 Recombinant Caspase 8 (CASP8) Positive Control; Immunogen; SDS-PAGE; WB.
RPA853Hu03 Recombinant Caspase 8 (CASP8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA853Hu01 Polyclonal Antibody to Caspase 8 (CASP8) WB,IHC,ICC/IF
MAA853Hu22 Monoclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IP.
PAA853Hu02 Polyclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IP.
LAA853Hu71 Biotin-Linked Polyclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC.
LAA853Hu81 FITC-Linked Polyclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IF.
PAA853Hu03 Polyclonal Antibody to Caspase 8 (CASP8) WB,IHC,ICC/IF
MAA853Hu21 Monoclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IP.
MAA853Hu23 Monoclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IP.
MAA853Hu25 Monoclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IP.
MAA853Hu24 Monoclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IP.
MAA853Hu29 Monoclonal Antibody to Caspase 8 (CASP8) WB
MAA853Hu27 Monoclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IP.
PAA853Hu04 Polyclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IP.
Assay Kits SEA853Hu ELISA Kit for Caspase 8 (CASP8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA853Mu01 Recombinant Caspase 8 (CASP8) Positive Control; Immunogen; SDS-PAGE; WB.
RPA853Mu02 Recombinant Caspase 8 (CASP8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA853Mu01 Polyclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IP.
LAA853Mu71 Biotin-Linked Polyclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC.
LAA853Mu81 FITC-Linked Polyclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IF.
PAA853Mu02 Polyclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IP.
Assay Kits SEA853Mu ELISA Kit for Caspase 8 (CASP8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA853Ra01 Recombinant Caspase 8 (CASP8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA853Ra01 Polyclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IP.
MAA853Ra21 Monoclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IP.
MAA853Ra23 Monoclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IP.
MAA853Ra22 Monoclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IP.
MAA853Ra24 Monoclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IP.
Assay Kits SEA853Ra ELISA Kit for Caspase 8 (CASP8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA853Bo01 Recombinant Caspase 8 (CASP8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA853Bo01 Polyclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IP.
LAA853Bo71 Biotin-Linked Polyclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC.
LAA853Bo81 FITC-Linked Polyclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IF.
MAA853Bo21 Monoclonal Antibody to Caspase 8 (CASP8) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Caspase 8 (CASP8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caspase 8 (CASP8) ELISA Kit Customized Service Offer
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  2. "FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex."Cell 85:817-827(1996) [PubMed] [Europe PMC] [Abstract]
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  6. "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2."Genomics 71:200-213(2001) [PubMed] [Europe PMC] [Abstract]
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  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  12. "FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens."J. Biol. Chem. 272:2952-2956(1997) [PubMed] [Europe PMC] [Abstract]
  13. "FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)."EMBO J. 16:2794-2804(1997) [PubMed] [Europe PMC] [Abstract]
  14. "Dominant expression of a novel splice variant of caspase-8 in human peripheral blood lymphocytes."Biochem. Biophys. Res. Commun. 272:877-881(2000) [PubMed] [Europe PMC] [Abstract]
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  17. "A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation."Proc. Natl. Acad. Sci. U.S.A. 98:7829-7834(2001) [PubMed] [Europe PMC] [Abstract]
  18. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Calcium binding of ARC mediates regulation of caspase 8 and cell death."Mol. Cell. Biol. 24:9763-9770(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth."Proc. Natl. Acad. Sci. U.S.A. 101:6170-6175(2004) [PubMed] [Europe PMC] [Abstract]
  21. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  22. "Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway."Oncogene 24:688-696(2005) [PubMed] [Europe PMC] [Abstract]
  23. "FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies."EMBO J. 26:391-401(2007) [PubMed] [Europe PMC] [Abstract]
  24. "Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity."Mol. Cell. Biol. 30:5726-5740(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  26. "The E. coli effector protein NleF is a caspase inhibitor."PLoS ONE 8:E58937-E58937(2013) [PubMed] [Europe PMC] [Abstract]
  27. "The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis."Structure 7:1125-1133(1999) [PubMed] [Europe PMC] [Abstract]
  28. "The atomic-resolution structure of human caspase-8, a key activator of apoptosis."Structure 7:1135-1143(1999) [PubMed] [Europe PMC] [Abstract]
  29. "Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency."Nature 419:395-399(2002) [PubMed] [Europe PMC] [Abstract]
  30. "Association of a common variant of the CASP8 gene with reduced risk of breast cancer."J. Natl. Cancer Inst. 96:1866-1869(2004) [PubMed] [Europe PMC] [Abstract]
  31. "A common coding variant in CASP8 is associated with breast cancer risk." Nat. Genet. 39:352-358(2007) [PubMed] [Europe PMC] [Abstract]
  32. Erratum Nat. Genet. 39:688-688(2007)
  33. "A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers."Nat. Genet. 39:605-613(2007) [PubMed] [Europe PMC] [Abstract]
  34. "Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma."Hum. Mutat. 29:1443-1451(2008) [PubMed] [Europe PMC] [Abstract]