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Cluster Of Differentiation 247 (CD247)

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CD3-ZETA; CD3H; CD3Q; CD3Z; TCRZ; TCR-Z; T-Cell Receptor Zeta; CD3z Antigen; Zeta Polypeptide TiT3 Complex; T-cell receptor T3 zeta chain

Cluster Of Differentiation 247 (CD247)
CCC A865
HGNC 1677
MGI 88334
PubMed 24343121
RGD 2305
UniProt P20963
Wiki CD247

T-cell receptor zeta, together with T-cell receptor alpha/beta and gamma/delta heterodimers and CD3-gamma, -delta, and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.Comparison of the human and murine genes showed a high degree of conservation, including conservation in the nucleotide sequence of the 5-prime and 3-prime untranslated regions. No significant sequence and structural homology was found, however, with the previously characterized invariant delta, gamma, and epsilon chains of the T-cell receptor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA865Hu01 Recombinant Cluster Of Differentiation 247 (CD247) Positive Control; Immunogen; SDS-PAGE; WB.
CPA865Hu21 OVA Conjugated Cluster Of Differentiation 247 (CD247) Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 247 (CD247) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 247 (CD247) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 247 (CD247) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 247 (CD247) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA865Mu01 Recombinant Cluster Of Differentiation 247 (CD247) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 247 (CD247) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 247 (CD247) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 247 (CD247) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 247 (CD247) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cluster Of Differentiation 247 (CD247) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 247 (CD247) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 247 (CD247) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 247 (CD247) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 247 (CD247) ELISA Kit Customized Service Offer
  1. "Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex."Proc. Natl. Acad. Sci. U.S.A. 85:9709-9713(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Zeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2."J. Virol. 72:9827-9834(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins."Oncogene 16:891-901(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain."J. Exp. Med. 189:1489-1496(1999) [PubMed] [Europe PMC] [Abstract]
  8. "SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling."Proc. Natl. Acad. Sci. U.S.A. 96:9775-9780(1999) [PubMed] [Europe PMC] [Abstract]
  9. "The transmembrane adaptor protein TRIM regulates T-cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain."J. Exp. Med. 193:1269-1284(2001) [PubMed] [Europe PMC] [Abstract]
  10. "DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription."Biochem. Biophys. Res. Commun. 296:716-720(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry."Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication."J. Virol. 79:10547-10560(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms."Cell 72:779-790(1993) [PubMed] [Europe PMC] [Abstract]
  18. "Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency."N. Engl. J. Med. 354:1913-1921(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor."Nature 377:32-38(1995) [PubMed] [Europe PMC] [Abstract]
  20. "Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor."Proc. Natl. Acad. Sci. U.S.A. 92:7784-7788(1995) [PubMed] [Europe PMC] [Abstract]
  21. "Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45."J. Exp. Med. 201:441-452(2005) [PubMed] [Europe PMC] [Abstract]
  22. "The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor."Cell 127:355-368(2006) [PubMed] [Europe PMC] [Abstract]