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Thyroid Hormone Receptor Beta (THRb)

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ERBA-BETA; ERBA2; GRTH; NR1A2; THR1; THRB1; THRB2; Erythroblastic Leukemia Viral(v-erb-a)Oncogene Homolog 2,Avian; Nuclear Receptor Subfamily 1,Group A,Member 2

Thyroid Hormone Receptor Beta (THRb)
CCC A869
HGNC 11799
MGI 98743
PubMed 10487671
RGD 3858
UniProt P10828
Wiki THRB

Thyroid hormone receptor beta (TR-beta) is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several transcript variants have been observed for this gene, but the full-length nature of only one has been observed so far.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA869Hu01 Recombinant Thyroid Hormone Receptor Beta (THRb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA869Hu01 Polyclonal Antibody to Thyroid Hormone Receptor Beta (THRb) WB; IHC; ICC; IP.
Assay Kits SEA869Hu ELISA Kit for Thyroid Hormone Receptor Beta (THRb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thyroid Hormone Receptor Beta (THRb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thyroid Hormone Receptor Beta (THRb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thyroid Hormone Receptor Beta (THRb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thyroid Hormone Receptor Beta (THRb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thyroid Hormone Receptor Beta (THRb) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thyroid Hormone Receptor Beta (THRb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thyroid Hormone Receptor Beta (THRb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thyroid Hormone Receptor Beta (THRb) Polyclonal Antibody Customized Service Offer
Assay Kits SEA869Ra ELISA Kit for Thyroid Hormone Receptor Beta (THRb) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human steroid receptors and erbA proto-oncogene products: members of a new superfamily of enhancer binding proteins."Cold Spring Harb. Symp. Quant. Biol. 51:759-772(1986) [PubMed] [Europe PMC] [Abstract]
  2. "The c-erb-A gene encodes a thyroid hormone receptor."Nature 324:641-646(1986) [PubMed] [Europe PMC] [Abstract]
  3. "Structural analysis of human thyroid hormone receptor beta gene."Mol. Cell. Endocrinol. 71:83-91(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Multiple messenger ribonucleic acid variants regulate cell-specific expression of human thyroid hormone receptor beta1."Mol. Endocrinol. 18:1631-1642(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A novel C-terminal domain in the thyroid hormone receptor selectively mediates thyroid hormone inhibition."J. Biol. Chem. 269:32713-32716(1994) [PubMed] [Europe PMC] [Abstract]
  9. "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function."Mol. Cell. Biol. 20:2604-2618(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha."J. Biol. Chem. 277:28624-28630(2002) [PubMed] [Europe PMC] [Abstract]
  11. "ERAP140, a conserved tissue-specific nuclear receptor coactivator."Mol. Cell. Biol. 22:3358-3372(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Human spot 14 protein interacts physically and functionally with the thyroid receptor."Biochem. Biophys. Res. Commun. 357:133-138(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Structural determinants of nuclear receptor assembly on DNA direct repeats."Nature 375:203-211(1995) [PubMed] [Europe PMC] [Abstract]
  14. "Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1."J. Med. Chem. 46:1580-1588(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain."Mol. Endocrinol. 17:107-116(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Two resistance to thyroid hormone mutants with impaired hormone binding."Mol. Endocrinol. 17:643-652(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor."Proc. Natl. Acad. Sci. U.S.A. 100:15358-15363(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Thyroxine-thyroid hormone receptor interactions."J. Biol. Chem. 279:55801-55808(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function."J. Mol. Biol. 360:586-598(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms."BMC Struct. Biol. 8:8-8(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Gaining ligand selectivity in thyroid hormone receptors via entropy."Proc. Natl. Acad. Sci. U.S.A. 106:20717-20722(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Molecular basis for dimer formation of TRbeta variant D355R."Proteins 75:111-117(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta."Proc. Natl. Acad. Sci. U.S.A. 86:8977-8981(1989) [PubMed] [Europe PMC] [Abstract]
  24. "A base mutation of the C-erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance. Molecular heterogeneity in two other kindreds."J. Clin. Invest. 85:93-100(1990) [PubMed] [Europe PMC] [Abstract]
  25. "A new point mutation in the 3,5,3'-triiodothyronine-binding domain of the c-erbA beta thyroid hormone receptor is tightly linked to generalized thyroid hormone resistance."J. Clin. Endocrinol. Metab. 72:32-38(1991) [PubMed] [Europe PMC] [Abstract]
  26. "Characterization of seven novel mutations of the c-erbA beta gene in unrelated kindreds with generalized thyroid hormone resistance. Evidence for two 'hot spot' regions of the ligand binding domain."J. Clin. Invest. 88:2123-2130(1991) [PubMed] [Europe PMC] [Abstract]
  27. "A homozygous deletion in the c-erbA beta thyroid hormone receptor gene in a patient with generalized thyroid hormone resistance: isolation and characterization of the mutant receptor."Mol. Endocrinol. 5:327-335(1991) [PubMed] [Europe PMC] [Abstract]
  28. "Functional properties of a novel mutant thyroid hormone receptor in a family with generalized thyroid hormone resistance syndrome."Clin. Endocrinol. (Oxf.) 36:281-289(1992) [PubMed] [Europe PMC] [Abstract]
  29. "An arginine to histidine mutation in codon 315 of the c-erbA beta thyroid hormone receptor in a kindred with generalized resistance to thyroid hormones results in a receptor with significant 3,5,3'-triiodothyronine binding activity."J. Clin. Endocrinol. Metab. 74:1164-1170(1992) [PubMed] [Europe PMC] [Abstract]
  30. "A point mutation in the 3,5,3'-triiodothyronine-binding domain of thyroid hormone receptor-beta associated with a family with generalized resistance to thyroid hormone."J. Clin. Endocrinol. Metab. 75:213-217(1992) [PubMed] [Europe PMC] [Abstract]
  31. "A point mutation of the T3 receptor beta 1 gene in a kindred of generalized resistance to thyroid hormone."Mol. Cell. Endocrinol. 84:159-166(1992) [PubMed] [Europe PMC] [Abstract]
  32. "A point mutation (Ala229 to Thr) in the hinge domain of the c-erbA beta thyroid hormone receptor gene in a family with generalized thyroid hormone resistance."Mol. Endocrinol. 6:1119-1126(1992) [PubMed] [Europe PMC] [Abstract]
  33. "An arginine to histidine mutation in codon 311 of the C-erbA beta gene results in a mutant thyroid hormone receptor that does not mediate a dominant negative phenotype."J. Clin. Invest. 91:538-546(1993) [PubMed] [Europe PMC] [Abstract]
  34. "Identical mutations in unrelated families with generalized resistance to thyroid hormone occur in cytosine-guanine-rich areas of the thyroid hormone receptor beta gene. Analysis of 15 families."J. Clin. Invest. 91:2408-2415(1993) [PubMed] [Europe PMC] [Abstract]
  35. "A new point mutation (C446R) in the thyroid hormone receptor-beta gene of a family with resistance to thyroid hormone."J. Clin. Endocrinol. Metab. 78:1253-1256(1994) [PubMed] [Europe PMC] [Abstract]
  36. "Resistance to thyroid hormone in subjects from two unrelated families is associated with a point mutation in the thyroid hormone receptor beta gene resulting in the replacement of the normal proline 453 with serine."Thyroid 4:249-254(1994) [PubMed] [Europe PMC] [Abstract]
  37. "New point mutation (R243W) in the hormone binding domain of the c-erbA beta 1 gene in a family with generalized resistance to thyroid hormone."Hum. Mutat. 7:79-81(1996) [PubMed] [Europe PMC] [Abstract]
  38. "Rapid molecular diagnosis of mutations associated with generalized thyroid hormone resistance by PCR-coupled automated direct sequencing of genomic DNA: detection of two novel mutations."Hum. Mutat. 8:247-257(1996) [PubMed] [Europe PMC] [Abstract]
  39. "T426I a new mutation in the thyroid hormone receptor gene in a sporadic patient with resistance to thyroid hormone and dysmorphism."Hum. Mutat. 12:289-289(1998) [PubMed] [Europe PMC] [Abstract]
  40. "Mosaicism of a thyroid hormone receptor-beta gene mutation in resistance to thyroid hormone."J. Clin. Endocrinol. Metab. 91:3471-3477(2006) [PubMed] [Europe PMC] [Abstract]
  41. "Genotyping of resistance to thyroid hormone in South American population. Identification of seven novel missense mutations in the human thyroid hormone receptor beta gene."Mol. Cell. Probes 23:148-153(2009) [PubMed] [Europe PMC] [Abstract]