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Insulin Receptor (INSR)

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CD220; ISR; HHF5; IR

Insulin Receptor (INSR)
CCC A895
HGNC 6091
MGI 96575
PubMed 8141246
RGD 2917
UniProt P06213
Wiki IR

In molecular biology, the insulin receptor is a transmembrane receptor that is activated by insulin. It belongs to the large class of tyrosine kinase receptors. Two alpha subunits and two beta subunits make up the insulin receptor. The beta subunits pass through the cellular membrane and are linked by disulfide bonds. The alpha and beta subunits are encoded by a single gene (INSR). The insulin receptor has also recently been designated CD220 .The main activity of activation of the insulin receptor is inducing glucose uptake. For this reason "insulin insensitivity", or a decrease in insulin receptor signaling, leads to diabetes mellitus type 2 - the cells are unable to take up glucose, and the result is hyperglycemia (an increase in circulating glucose), and all the sequelae which result from diabetes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA895Hu01 Recombinant Insulin Receptor (INSR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA895Hu02 Recombinant Insulin Receptor (INSR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA895Hu03 Recombinant Insulin Receptor (INSR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA895Hu04 Recombinant Insulin Receptor (INSR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA895Hu05 Recombinant Insulin Receptor (INSR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA895Hu06 Recombinant Insulin Receptor (INSR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA895Hu01 Polyclonal Antibody to Insulin Receptor (INSR) WB; IHC; ICC/IF
MAA895Hu22 Monoclonal Antibody to Insulin Receptor (INSR) WB; IF
PAA895Hu02 Polyclonal Antibody to Insulin Receptor (INSR) WB; IHC; ICC; IP.
PAA895Hu03 Polyclonal Antibody to Insulin Receptor (INSR) WB; IHC; ICC; IP.
LAA895Hu71 Biotin-Linked Polyclonal Antibody to Insulin Receptor (INSR) WB; IHC; ICC.
LAA895Hu81 FITC-Linked Polyclonal Antibody to Insulin Receptor (INSR) WB; IHC; ICC; IF.
MAA895Hu21 Monoclonal Antibody to Insulin Receptor (INSR) WB; IHC; ICC; IP.
MAA895Hu23 Monoclonal Antibody to Insulin Receptor (INSR) WB; IHC; ICC; IP.
MAA895Hu24 Monoclonal Antibody to Insulin Receptor (INSR) WB; IHC
MAA895Hu25 Monoclonal Antibody to Insulin Receptor (INSR) WB; IHC; ICC; IP.
MAA895Hu27 Monoclonal Antibody to Insulin Receptor (INSR) WB; IHC; ICC; IP.
Assay Kits AEA895Hu ELISA Kit for Anti-Insulin Receptor Antibody (Anti-INSR) Enzyme-linked immunosorbent assay for Antibody Detection.
SEA895Hu ELISA Kit for Insulin Receptor (INSR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA895Mu01 Recombinant Insulin Receptor (INSR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA895Mu01 Polyclonal Antibody to Insulin Receptor (INSR) WB; IHC; ICC; IP.
PAA895Mu02 Polyclonal Antibody to Insulin Receptor (INSR) WB; IHC; ICC; IP.
LAA895Mu81 FITC-Linked Polyclonal Antibody to Insulin Receptor (INSR) WB; IHC; ICC; IF.
Assay Kits SEA895Mu ELISA Kit for Insulin Receptor (INSR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA895Ra01 Recombinant Insulin Receptor (INSR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA895Ra01 Polyclonal Antibody to Insulin Receptor (INSR) WB; IHC; ICC; IP.
MAA895Ra21 Monoclonal Antibody to Insulin Receptor (INSR) WB; IHC; ICC; IP.
MAA895Ra22 Monoclonal Antibody to Insulin Receptor (INSR) WB; IHC; ICC; IP.
Assay Kits SEA895Ra ELISA Kit for Insulin Receptor (INSR) Enzyme-linked immunosorbent assay for Antigen Detection.
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  104. "The Val985Met insulin-receptor variant in the Danish Caucasian population: lack of associations with non-insulin-dependent diabetes mellitus or insulin resistance."Am. J. Hum. Genet. 60:1532-1535(1997) [PubMed] [Europe PMC] [Abstract]
  105. "Identification of two novel insulin receptor mutations, Asp59Gly and Leu62Pro, in type A syndrome of extreme insulin resistance."Biochem. Biophys. Res. Commun. 234:764-768(1997) [PubMed] [Europe PMC] [Abstract]
  106. "Four mutant alleles of the insulin receptor gene associated with genetic syndromes of extreme insulin resistance."Biochem. Biophys. Res. Commun. 237:516-520(1997) [PubMed] [Europe PMC] [Abstract]
  107. "Molecular analysis of the insulin receptor gene for prenatal diagnosis of leprechaunism in two families."Prenat. Diagn. 17:657-663(1997) [PubMed] [Europe PMC] [Abstract]
  108. "Multiple molecular mechanisms of insulin receptor dysfunction in a patient with Donohue syndrome."Diabetes 47:1362-1364(1998) [PubMed] [Europe PMC] [Abstract]
  109. "Progressive decline in insulin levels in Rabson-Mendenhall syndrome."J. Clin. Endocrinol. Metab. 84:2623-2629(1999) [PubMed] [Europe PMC] [Abstract]
  110. "Identification of three novel mutations in the insulin receptor gene in type A insulin resistant patients."Clin. Genet. 57:67-69(2000) [PubMed] [Europe PMC] [Abstract]
  111. "Identification of novel C253Y missense and Y864X nonsense mutations in the insulin receptor gene in type A insulin-resistant patients."Clin. Genet. 59:194-197(2001) [PubMed] [Europe PMC] [Abstract]
  112. "An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events."Diabetologia 45:657-667(2002) [PubMed] [
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