Alpha-Crosslaps (aCTx)

Urinary CrossLaps (CTx) has been reported to be a sensitive bone for osteoporosis and metabolic bone disease. The values of the urinary nonisomerized (ALPHA) and isomerized (BETA) CTx in postmenopausal women increased compared to those in premenopausal women. However, the degree of increase of urinary ALPHA-CTx after menopause is relatively less than BETA-CTx. In patients with primary hyperparathyroid and hyperthyroid patients, ALPHA-CTx and BETA-CTx increased by the same extent. In contrast, in paget's disease, ALPHA-CTx Was remarkably increased in comparison with BETA-CTx. The values of the urinary ALPHA-CTx and BETA-CTx in patients with vertebral fracture (VX) and patients with hip fracture (HX) was increased in comparison with those in postmenopausal women. However, the degree of increase of urinary BETA-CTx in osteoporotic patients with fracture is relatively less than ALPHA-CTx.