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Chemokine C-C-Motif Receptor 5 (CCR5)

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CD195; CC-CKR5; CCCKR5; CMKBR5; CHEMR13; HIV-1 fusion coreceptor

Chemokine C-C-Motif Receptor 5 (CCR5)
CCC A906
HGNC 1606
MGI 107182
PubMed 12402506
RGD 620596
UniProt P51681
Wiki CCR5

CCR5 is a member of the beta chemokine receptors family of integral membrane proteins.In Humans, the CCR5 gene location is on the short (p) arm at position 21 on chromosome 3. Certain populations have inherited the Delta 32 mutation resulting in the Genetic deletion of the CCR5 gene. Homozygous carriers of this mutation are resistant to HIV-1 infection. The CCR5 protein is a seven transmembrane protein which functions as a chemokine receptor in the CC chemokine group. The natural chemokine ligands that bind to this receptor are RANTES, MIP-1α and MIP-1β. CCR5 is predominantly expressed on T cells, macrophages, dendritic cells and microglia. It is likely that CCR5 plays a role in inflammatory responses to infection, though its exact role in normal immune function is unclear.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA906Hu01 Recombinant Chemokine C-C-Motif Receptor 5 (CCR5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA906Hu01 Polyclonal Antibody to Chemokine C-C-Motif Receptor 5 (CCR5) WB; IHC; ICC; IP.
MAA906Hu21 Monoclonal Antibody to Chemokine C-C-Motif Receptor 5 (CCR5) WB; IHC; ICC; IP.
Assay Kits SEA906Hu ELISA Kit for Chemokine C-C-Motif Receptor 5 (CCR5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA906Mu01 Recombinant Chemokine C-C-Motif Receptor 5 (CCR5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA906Mu01 Polyclonal Antibody to Chemokine C-C-Motif Receptor 5 (CCR5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Chemokine C-C-Motif Receptor 5 (CCR5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chemokine C-C-Motif Receptor 5 (CCR5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA906Ra01 Recombinant Chemokine C-C-Motif Receptor 5 (CCR5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA906Ra01 Polyclonal Antibody to Chemokine C-C-Motif Receptor 5 (CCR5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Chemokine C-C-Motif Receptor 5 (CCR5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chemokine C-C-Motif Receptor 5 (CCR5) ELISA Kit Customized Service Offer
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  20. "Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity."Blood 119:4908-4918(2012) [PubMed] [Europe PMC] [Abstract]
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  23. "The conformation and orientation of a 27-residue CCR5 peptide in a ternary complex with HIV-1 gp120 and a CD4-mimic peptide."J. Mol. Biol. 410:778-797(2011) [PubMed] [Europe PMC] [Abstract]
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  27. "Shared and distinct genetic variants in type 1 diabetes and celiac disease."N. Engl. J. Med. 359:2767-2777(2008) [PubMed] [Europe PMC] [Abstract]
  28. "CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum."Traffic 15:383-400(2014) [PubMed] [Europe PMC] [Abstract]