≡

Retinol Binding Protein 4 (RBP4)

[Edit]

PRBP; RBP; Plasma retinol-binding protein; Retinol Binding Protein 4, Plasma

Retinol Binding Protein 4 (RBP4)
CCC A929
HGNC 9922
MGI 97879
PubMed 21711327
RGD 3546
UniProt P02753
Wiki RBP4

Retinol binding protein (RBP) 4 is the only specific transport protein for vitamin A in the circulation whose function is to deliver vitamin to target tissues. In obesity and type 2 diabetes, expression of Glut4 is significantly impaired in adipocytes. Glucose transport via Glut4 is the rate-limiting step for glucose use by muscle and adipose tissue.

Yang et al. noted that adipocytespecific deletion of Gluts led to notable elevation of RBP4 causing systemic insulin resistance, and that reduction of RBP4 improved insulin resistance. This identified a novel role of RBP4 in regulating insulin action and RBP4 is recorded as an adipocytederived hormone. Thus, measurement of serum or plasma RBP4 is a useful means for understanding of metabolic disorders.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA929Hu01 Recombinant Retinol Binding Protein 4 (RBP4) Positive Control; Immunogen; SDS-PAGE; WB.
EPA929Hu61 Eukaryotic Retinol Binding Protein 4 (RBP4) Positive Control; Immunogen; SDS-PAGE; WB.
APA929Hu61 Active Retinol Binding Protein 4 (RBP4) Cell culture; Activity Assays.
APA929Hu01 Active Retinol Binding Protein 4 (RBP4) Cell culture; Activity Assays.
Antibodies PAA929Hu01 Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IP.
MAA929Hu22 Monoclonal Antibody to Retinol Binding Protein 4 (RBP4) WB,IHC
LAA929Hu71 Biotin-Linked Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC.
LAA929Hu81 FITC-Linked Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IF.
PAA929Hu06 Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IP.
MAA929Hu26 Monoclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IP.
MAA929Hu21 Monoclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IP.
MAA929Hu23 Monoclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IP.
MAA929Hu29 Monoclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IP.
MAA929Hu25 Monoclonal Antibody to Retinol Binding Protein 4 (RBP4) WB
MAA929Hu27 Monoclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IP.
MAA929Hu24 Monoclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IP.
Assay Kits SEA929Hu ELISA Kit for Retinol Binding Protein 4 (RBP4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA929Mu01 Recombinant Retinol Binding Protein 4 (RBP4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA929Mu02 Recombinant Retinol Binding Protein 4 (RBP4) Positive Control; Immunogen; SDS-PAGE; WB.
APA929Mu01 Active Retinol Binding Protein 4 (RBP4) Cell culture; Activity Assays.
Antibodies PAA929Mu01 Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IP.
LAA929Mu71 Biotin-Linked Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC.
LAA929Mu81 FITC-Linked Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IF.
PAA929Mu02 Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IP.
Assay Kits SEA929Mu ELISA Kit for Retinol Binding Protein 4 (RBP4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA929Ra01 Recombinant Retinol Binding Protein 4 (RBP4) Positive Control; Immunogen; SDS-PAGE; WB.
APA929Ra01 Active Retinol Binding Protein 4 (RBP4) Cell culture; Activity Assays.
Antibodies PAA929Ra01 Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IP.
MAA929Ra21 Monoclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IP.
Assay Kits SEA929Ra ELISA Kit for Retinol Binding Protein 4 (RBP4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA929Rb01 Recombinant Retinol Binding Protein 4 (RBP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA929Rb51 Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IP.
PAA929Rb52 Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Retinol Binding Protein 4 (RBP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinol Binding Protein 4 (RBP4) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA929Po01 Recombinant Retinol Binding Protein 4 (RBP4) Positive Control; Immunogen; SDS-PAGE; WB.
APA929Po01 Active Retinol Binding Protein 4 (RBP4) Cell culture; Activity Assays.
Antibodies PAA929Po01 Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IP.
LAA929Po71 Biotin-Linked Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC.
Assay Kits SEA929Po ELISA Kit for Retinol Binding Protein 4 (RBP4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA929Bo01 Recombinant Retinol Binding Protein 4 (RBP4) Positive Control; Immunogen; SDS-PAGE; WB.
APA929Bo02 Active Retinol Binding Protein 4 (RBP4) Cell culture; Activity Assays.
RPA929Bo02 Recombinant Retinol Binding Protein 4 (RBP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA929Bo01 Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC
LAA929Bo71 Biotin-Linked Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC.
LAA929Bo81 FITC-Linked Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IF.
MAA929Bo21 Monoclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IP.
PAA929Bo02 Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IP.
Assay Kits SEA929Bo ELISA Kit for Retinol Binding Protein 4 (RBP4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA929Ga01 Recombinant Retinol Binding Protein 4 (RBP4) Positive Control; Immunogen; SDS-PAGE; WB.
APA929Ga01 Active Retinol Binding Protein 4 (RBP4) Cell culture; Activity Assays.
Antibodies PAA929Ga01 Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IP.
LAA929Ga71 Biotin-Linked Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC.
LAA929Ga81 FITC-Linked Polyclonal Antibody to Retinol Binding Protein 4 (RBP4) WB; IHC; ICC; IF.
Assay Kits SEA929Ga ELISA Kit for Retinol Binding Protein 4 (RBP4) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning and sequencing of a full length cDNA coding for human retinol-binding protein."Nucleic Acids Res. 11:7769-7776(1983) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Structure and cell-specific expression of a cloned human retinol binding protein gene: the 5'-flanking region contains hepatoma specific transcriptional signals."EMBO J. 4:1981-1989(1985) [PubMed] [Europe PMC] [Abstract]
  5. "The complete amino acid sequence of human serum retinol-binding protein."Ups. J. Med. Sci. 92:115-146(1987) [PubMed] [Europe PMC] [Abstract]
  6. "Structural and functional studies of vitamin A-binding proteins."Ann. N. Y. Acad. Sci. 359:79-90(1981) [PubMed] [Europe PMC] [Abstract]
  7. "The primary structure of the human retinol-binding protein."FEBS Lett. 104:55-58(1979) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of two post-translationally processed forms of human serum retinol-binding protein: altered ratios in chronic renal failure."J. Lipid Res. 36:1247-1253(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Comparative phenotypic analyses of human plasma and urinary retinol binding protein using mass spectrometric immunoassay."Biochem. Biophys. Res. Commun. 297:401-405(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Comparative urine protein phenotyping using mass spectrometric immunoassay."J. Proteome Res. 2:191-197(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Exome analysis identified a novel mutation in the RBP4 gene in a consanguineous pedigree with retinal dystrophy and developmental abnormalities."PLoS ONE 7:E50205-E50205(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "The three-dimensional structure of retinol-binding protein."EMBO J. 3:1451-1454(1984) [PubMed] [Europe PMC] [Abstract]
  15. "Crystallographic refinement of human serum retinol binding protein at 2-A resolution."Proteins 8:44-61(1990) [PubMed] [Europe PMC] [Abstract]
  16. "Three-dimensional structure and active site of three hydrophobic molecule-binding proteins with significant amino acid sequence similarity."Biopolymers 32:457-465(1992) [PubMed] [Europe PMC] [Abstract]
  17. "The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP."Biochemistry 38:2647-2653(1999) [PubMed] [Europe PMC] [Abstract]
  18. "Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis."Invest. Ophthalmol. Vis. Sci. 40:3-11(1999) [PubMed] [Europe PMC] [Abstract]
  19. "Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein."Am. J. Clin. Nutr. 69:931-936(1999) [PubMed] [Europe PMC] [Abstract]