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Protein Interacting With C Kinase 1 (PICK1)

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PRKCABP; Protein kinase C,Alpha Binding Protein; Protein Interacting With Protein Kinase C Alpha 1; Protein kinase C-alpha-binding protein

Protein Interacting With C Kinase 1 (PICK1)
CCC A931
HGNC 9394
MGI 894645
PubMed 22915106
RGD 69437
UniProt Q9NRD5
Wiki PICK1

PRKCA-binding protein is a protein contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function.

This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Interacting With C Kinase 1 (PICK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Interacting With C Kinase 1 (PICK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Interacting With C Kinase 1 (PICK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Interacting With C Kinase 1 (PICK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Interacting With C Kinase 1 (PICK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA931Mu01 Recombinant Protein Interacting With C Kinase 1 (PICK1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA931Mu02 Recombinant Protein Interacting With C Kinase 1 (PICK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA931Mu01 Polyclonal Antibody to Protein Interacting With C Kinase 1 (PICK1) WB; IHC; ICC; IP.
PAA931Mu02 Polyclonal Antibody to Protein Interacting With C Kinase 1 (PICK1) WB; IHC; ICC; IP.
Assay Kits SEA931Mu ELISA Kit for Protein Interacting With C Kinase 1 (PICK1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Interacting With C Kinase 1 (PICK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Interacting With C Kinase 1 (PICK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Interacting With C Kinase 1 (PICK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Interacting With C Kinase 1 (PICK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Interacting With C Kinase 1 (PICK1) ELISA Kit Customized Service Offer
  1. "Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors."Biochem. Biophys. Res. Commun. 267:149-155(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Reevaluating human gene annotation: a second-generation analysis of chromosome 22."Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract]
  3. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering."Mol. Pharmacol. 60:916-923(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1."Neuron 30:121-134(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)."Biochem. J. 361:443-450(2002) [PubMed] [Europe PMC] [Abstract]
  10. "A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth."J. Cell Sci. 117:4401-4409(2004) [PubMed] [Europe PMC] [Abstract]
  11. "The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands."J. Biol. Chem. 279:41393-41397(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Threonine 82 at the PDZ domain of PICK1 is critical for AMPA receptor interaction and localization."Neurochem. Int. 56:962-970(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions."Protein Sci. 16:683-694(2007) [PubMed] [Europe PMC] [Abstract]