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Pre-B-Lymphocyte Gene 1 (VPREB1)

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CD179A; IGVPB; VPREB; IGI; Immunoglobulin Iota Chain; CD179 antigen-like family member A; Protein VPreB1; V(pre)B protein

Pre-B-Lymphocyte Gene 1 (VPREB1)
CCC A942
HGNC 12709
MGI 98936
PubMed 21144590
RGD 1588558
UniProt P12018
Wiki VPREB1

CD179a (VpreB) is a 126 aa-long polypeptide with apparent MW of 16-18 kDa. It is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. CD179a has an Ig V domain-like structure, but lacks the last beta-strand (beta7) of a typical V domain. Instead, it has a carboxyl terminal end that shows no sequence homologies to any other proteins.

CD179a associates non-covalently with CD179b (lambda5 or lambda-like) carrying an Ig C domain-like structure to form an Ig light chain-like structure, which is called the surrogate light chain or pseudo light chain. In this complex, the incomplete V domain of CD179a appears to be complemented by the extra beta7 strand of CD179b.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA942Hu01 Recombinant Pre-B-Lymphocyte Gene 1 (VPREB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA942Hu01 Polyclonal Antibody to Pre-B-Lymphocyte Gene 1 (VPREB1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Pre-B-Lymphocyte Gene 1 (VPREB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-B-Lymphocyte Gene 1 (VPREB1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA942Mu01 Recombinant Pre-B-Lymphocyte Gene 1 (VPREB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA942Mu01 Polyclonal Antibody to Pre-B-Lymphocyte Gene 1 (VPREB1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Pre-B-Lymphocyte Gene 1 (VPREB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-B-Lymphocyte Gene 1 (VPREB1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA942Ra01 Recombinant Pre-B-Lymphocyte Gene 1 (VPREB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA942Ra01 Polyclonal Antibody to Pre-B-Lymphocyte Gene 1 (VPREB1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Pre-B-Lymphocyte Gene 1 (VPREB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-B-Lymphocyte Gene 1 (VPREB1) ELISA Kit Customized Service Offer
  1. "The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain."Mol. Immunol. 31:1099-1108(1994) [PubMed] [Europe PMC] [Abstract]
  2. "One-megabase sequence analysis of the human immunoglobulin lambda gene locus."Genome Res. 7:250-261(1997) [PubMed] [Europe PMC] [Abstract]
  3. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Structure and pre-B lymphocyte restricted expression of the VpreB in humans and conservation of its structure in other mammalian species."EMBO J. 7:111-116(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Structural insight into pre-B cell receptor function."Science 316:291-294(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Engineering and characterization of a single chain surrogate light chain variable domain."Protein Sci. 17:458-465(2008) [PubMed] [Europe PMC] [Abstract]