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Fucosyltransferase 3 (FUT3)

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CD174; FUT3; FT3B; LE; Les; FucT-III; Lewis FT; Galactoside 3(4)-L-Fucosyltransferase, Lewis Blood Group; Blood group Lewis alpha-4-fucosyltransferase

Fucosyltransferase 3 (FUT3)
CCC A944
HGNC 4014
PubMed 9703429
UniProt P21217
Wiki FUT3

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA944Hu01 Recombinant Fucosyltransferase 3 (FUT3) Positive Control; Immunogen; SDS-PAGE; WB.
RPA944Hu02 Recombinant Fucosyltransferase 3 (FUT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA944Hu01 Polyclonal Antibody to Fucosyltransferase 3 (FUT3) WB; IHC; ICC; IP.
MAA944Hu22 Monoclonal Antibody to Fucosyltransferase 3 (FUT3) WB; IHC; ICC; IP.
Assay Kits SEA944Hu ELISA Kit for Fucosyltransferase 3 (FUT3) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase."Genes Dev. 4:1288-1303(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms."J. Biol. Chem. 270:20112-20122(1995) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Genotypic heterogeneity among Lewis negative individuals."Biochem. Biophys. Res. Commun. 196:515-520(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Alpha (1,3/1,4)fucosyltransferase (FucT-III) gene is inactivated by a single amino acid substitution in Lewis histo-blood type negative individuals."Biochem. Biophys. Res. Commun. 196:624-631(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals."Blood 82:2915-2919(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular basis for Lewis alpha(1,3/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees."J. Biol. Chem. 269:20987-20994(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Molecular genetic analysis of the human Lewis histo-blood group system."J. Biol. Chem. 269:29271-29278(1994) [PubMed] [Europe PMC] [Abstract]
  10. "DNA sequencing and screening for point mutations in the human Lewis 'FUT3' gene enables molecular genotyping of the human Lewis blood group system."Vox Sang. 70:97-103(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Significance of individual point mutations, T202C and C314T, in the human Lewis 'FUT3' gene for expression of Lewis antigens by the human alpha'1,3/1,4'-fucosyltransferase, Fuc-TIII."J. Biol. Chem. 272:21994-21998(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Five novel missense mutations of the Lewis gene 'FUT3' in African 'Xhosa' and Caucasian populations in South Africa."Hum. Genet. 102:675-680(1998) [PubMed] [Europe PMC] [Abstract]