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Chemerin (CHEM)

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TIG2; RARRES2; Tazarotene-Induced Gene 2; Retinoic Acid Receptor Responder 2,Tazarotene Induced; RAR-responsive protein TIG2

Chemerin (CHEM)
CCC A945
HGNC 9868
MGI 1918910
PubMed 20237162
RGD 1309874
UniProt Q99969
Wiki Chemerin

Chemerin is a novel protein identified as the natural ligand of ChemR23 (chemerinR), a previously orphan G protein-coupled receptor expressed in immature dendritic cells and macrophages. It is a member of the Cystatin superfamily. Chemerin is synthesized as a 163 aa secreted precursor, prochemerin, which contains a hydrophobic 20 aa N-terminal sequence, an intervening 137 aa Cystatin fold-containing domain, and a six aa C-terminal prosegment. It is activated by proteases of the coagulation, fibrinolytic, and inflammatory cascades and converted into a full agonist of chemerinR by proteolytic removal of the last six amino acids.Chemerin is a chemoattractant for cells bearing the Chem R23 receptor, including plasmacytoid dendritic cells and tissue macrophages.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA945Hu01 Recombinant Chemerin (CHEM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA945Hu01 Polyclonal Antibody to Chemerin (CHEM) WB; IHC; ICC; IP.
MAA945Hu22 Monoclonal Antibody to Chemerin (CHEM) WB; IHC
LAA945Hu54 APC-Linked Monoclonal Antibody to Chemerin (CHEM) WB; IHC; ICC; IF.
MAA945Hu21 Monoclonal Antibody to Chemerin (CHEM) WB; IHC; ICC; IP.
MAA945Hu23 Monoclonal Antibody to Chemerin (CHEM) WB; IHC; ICC; IP.
Assay Kits SEA945Hu ELISA Kit for Chemerin (CHEM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA945Mu01 Recombinant Chemerin (CHEM) Positive Control; Immunogen; SDS-PAGE; WB.
RPA945Mu02 Recombinant Chemerin (CHEM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA945Mu01 Polyclonal Antibody to Chemerin (CHEM) WB,IHC
PAA945Mu02 Polyclonal Antibody to Chemerin (CHEM) WB; IHC; ICC; IP.
Assay Kits SEA945Mu ELISA Kit for Chemerin (CHEM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA945Ra01 Recombinant Chemerin (CHEM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA945Ra01 Polyclonal Antibody to Chemerin (CHEM) WB; IHC; ICC; IP.
LAA945Ra91 HRP-Linked Polyclonal Antibody to Chemerin (CHEM) WB; IHC; ICC.
MAA945Ra21 Monoclonal Antibody to Chemerin (CHEM) WB; IHC; ICC; IP.
MAA945Ra22 Monoclonal Antibody to Chemerin (CHEM) WB
MAA945Ra24 Monoclonal Antibody to Chemerin (CHEM) WB; IHC; ICC; IP.
MAA945Ra23 Monoclonal Antibody to Chemerin (CHEM) WB; IHC; ICC; IP.
MAA945Ra25 Monoclonal Antibody to Chemerin (CHEM) WB; IHC; ICC; IP.
Assay Kits SEA945Ra ELISA Kit for Chemerin (CHEM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chemerin (CHEM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chemerin (CHEM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chemerin (CHEM) Polyclonal Antibody Customized Service Offer
Assay Kits SEA945Po ELISA Kit for Chemerin (CHEM) Enzyme-linked immunosorbent assay for Antigen Detection.
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  8. "Chemerin--a new adipokine that modulates adipogenesis via its own receptor."Biochem. Biophys. Res. Commun. 362:1013-1018(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism."J. Biol. Chem. 282:28175-28188(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes."FEBS Lett. 582:573-578(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Proteolytic regulatory mechanism of chemerin bioactivity."Acta Biochim. Biophys. Sin. 41:973-979(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Chemerin, a novel adipokine in the regulation of angiogenesis."J. Clin. Endocrinol. Metab. 95:2476-2485(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Chemerin: at the crossroads of inflammation and obesity."Trends Endocrinol. Metab. 21:660-667(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism."Cytokine Growth Factor Rev. 22:331-338(2011) [PubMed] [Europe PMC] [Abstract]
  15. "A novel adipocytokine, chemerin exerts anti-inflammatory roles in human vascular endothelial cells."Biochem. Biophys. Res. Commun. 423:152-157(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Chemerin: a potential endocrine link between obesity and type 2 diabetes."Endocrine 42:243-251(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Towards an integrative approach to understanding the role of chemerin in human health and disease."Obes. Rev. 14:245-262(2013) [PubMed] [Europe PMC] [Abstract]
  18. "Chemerin is an antimicrobial agent in human epidermis."PLoS ONE 8:E58709-E58709(2013) [PubMed] [Europe PMC] [Abstract]