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Signal Regulatory Protein Gamma (SIRPg)

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CD172g; CD172-G; SIRP-G; SIRP-B2; SIRPB2; SIRP-b2; SIRP-beta-2; SIRPgamma; CD172 antigen-like family member B; Signal-regulatory protein beta-2

Signal Regulatory Protein Gamma (SIRPg)
CCC A947
HGNC 15757
PubMed 19473566
UniProt Q9P1W8
Wiki SIRPG

Signal-regulatory protein gamma is a protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.

The 354-amino acid protein shares approximately 75% sequence identity with SIRPB1. It possesses a putative signal sequence, a long extracellular domain, a transmembrane region, a short intracellular domain, and no catalytic domain. RT-PCR analysis detected expression of SIRPG at varying levels in all tissues tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA947Hu01 Recombinant Signal Regulatory Protein Gamma (SIRPg) Positive Control; Immunogen; SDS-PAGE; WB.
RPA947Hu02 Recombinant Signal Regulatory Protein Gamma (SIRPg) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA947Hu01 Polyclonal Antibody to Signal Regulatory Protein Gamma (SIRPg) WB
MAA947Hu21 Monoclonal Antibody to Signal Regulatory Protein Gamma (SIRPg) WB; IHC; ICC; IP.
Assay Kits SEA947Hu ELISA Kit for Signal Regulatory Protein Gamma (SIRPg) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family."J. Hum. Genet. 45:378-382(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation."Blood 105:2421-2427(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47."Mol. Cell 31:266-277(2008) [PubMed] [Europe PMC] [Abstract]