≡

Thymidine Phosphorylase (TP)

[Edit]

TYMP; PDECGF; ECGF1; MNGIE; TP; HPD-ECGF; TdRPase; Platelet-Derived Endothelial Cell Growth Factor; Gliostatin

Thymidine Phosphorylase (TP)
CCC A948
HGNC 3148
MGI 1920212
PubMed 9924029
RGD 1305756
UniProt P19971
Wiki TYMP

  • Platelet-derived endothelial cell growth factor is a novel angiogenic factor distinct from the previously described endothelial cell mitogens of the fibroblast growth factor family. PD-ECGF, which is stored in platelets as a 45-kD single polypeptide chain, has a highly restricted target cell specificity acting only on endothelial cells. It promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells.

  • Cloning of the gene revealed that it contains 10 exons spanning more than 4.3 kb .Using an ECGF1 cDNA probe, Stenman et al. assigned the ECGF1 gene to chromosome 22 by analysis of its segregation in a panel of human/rodent somatic cell hybrids. By in situ hybridization, they sublocalized the gene to 22q13.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA948Hu01 Recombinant Thymidine Phosphorylase (TP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA948Hu01 Polyclonal Antibody to Thymidine Phosphorylase (TP) WB; IHC; ICC; IP.
MAA948Hu22 Monoclonal Antibody to Thymidine Phosphorylase (TP) WB; IHC; ICC; IP.
Assay Kits SEA948Hu ELISA Kit for Thymidine Phosphorylase (TP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA948Mu01 Recombinant Thymidine Phosphorylase (TP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA948Mu02 Recombinant Thymidine Phosphorylase (TP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA948Mu01 Polyclonal Antibody to Thymidine Phosphorylase (TP) WB; IHC; ICC; IP.
PAA948Mu02 Polyclonal Antibody to Thymidine Phosphorylase (TP) WB; IHC; ICC; IP.
Assay Kits SEA948Mu ELISA Kit for Thymidine Phosphorylase (TP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA948Ra01 Recombinant Thymidine Phosphorylase (TP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA948Ra01 Polyclonal Antibody to Thymidine Phosphorylase (TP) WB; IHC; ICC; IP.
LAA948Ra81 FITC-Linked Polyclonal Antibody to Thymidine Phosphorylase (TP) WB; IHC; ICC; IF.
LAA948Ra71 Biotin-Linked Polyclonal Antibody to Thymidine Phosphorylase (TP) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Thymidine Phosphorylase (TP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thymidine Phosphorylase (TP) ELISA Kit Customized Service Offer
  1. "Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor."Nature 338:557-562(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of recombinant platelet-derived endothelial cell growth factor in the yeast Saccharomyces cerevisiae."Yeast 8:57-60(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Angiogenic factor."Nature 356:668-668(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Neurotrophic action of gliostatin on cortical neurons. Identity of gliostatin and platelet-derived endothelial cell growth factor."J. Biol. Chem. 267:20311-20316(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity."Biochem. Biophys. Res. Commun. 184:1311-1316(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor."Structure 12:75-84(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design."Biochem. J. 399:199-204(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Structures of native human thymidine phosphorylase and in complex with 5-iodouracil."Biochem. Biophys. Res. Commun. 386:666-670(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder."Science 283:689-692(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Phenotypic variability in a Spanish family with MNGIE."Neurology 59:455-457(2002) [PubMed] [Europe PMC] [Abstract]