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Cluster Of Differentiation 6 (CD6)

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TP120; T12; T-cell differentiation antigen CD6

Cluster Of Differentiation 6 (CD6)
CCC A952
HGNC 1691
MGI 103566
PubMed 16914752
RGD 2312
UniProt P30203
Wiki CD6

CD6 is a monomeric 105- or 130-kD membrane glycoprotein that is involved in T-cell activation. The size difference between the 2 CD6 forms is due to differences in phosphorylation .

By screening a human peripheral blood acute lymphocytic leukemia cell cDNA expression library with antibodies against CD6, Aruffo et al. (1991) cloned a cDNA encoding CD6. The predicted 468-amino acid protein contains a 24-amino acid signal sequence, 3 extracellular 'scavenger receptor cysteine-rich' (SRCR) domains, a membrane-spanning domain, and a 44-amino acid cytoplasmic domain. It shows significant homology to CD5 . By Northern blot analysis, CD6 is expressed as an approximately 3-kb mRNA in T cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA952Hu01 Recombinant Cluster Of Differentiation 6 (CD6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA952Hu01 Polyclonal Antibody to Cluster Of Differentiation 6 (CD6) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 6 (CD6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 6 (CD6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA952Mu01 Recombinant Cluster Of Differentiation 6 (CD6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA952Mu01 Polyclonal Antibody to Cluster Of Differentiation 6 (CD6) WB; IHC; ICC; IP; FCM
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 6 (CD6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 6 (CD6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA952Ra01 Recombinant Cluster Of Differentiation 6 (CD6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA952Ra01 Polyclonal Antibody to Cluster Of Differentiation 6 (CD6) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 6 (CD6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 6 (CD6) ELISA Kit Customized Service Offer
  1. "Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms."J. Immunol. 158:1149-1156(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins."J. Exp. Med. 174:949-952(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse."J. Immunol. 178:4351-4361(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule."J. Biol. Chem. 266:7137-7143(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors."J. Exp. Med. 177:219-223(1993) [PubMed] [Europe PMC] [Abstract]