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Signal Regulatory Protein Alpha (SIRPa)

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CD172a; SIRP-A; P84; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP; Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1; Macrophage fusion receptor

Signal Regulatory Protein Alpha (SIRPa)
CCC A953
HGNC 9662
MGI 108563
PubMed 22451913
RGD 3449
UniProt P78324
Wiki SIRPA

Signal-regulatory protein alpha is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA953Hu01 Recombinant Signal Regulatory Protein Alpha (SIRPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA953Hu01 Polyclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB
MAA953Hu21 Monoclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IP.
Assay Kits SEA953Hu ELISA Kit for Signal Regulatory Protein Alpha (SIRPa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA953Mu01 Recombinant Signal Regulatory Protein Alpha (SIRPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA953Mu01 Polyclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Signal Regulatory Protein Alpha (SIRPa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Regulatory Protein Alpha (SIRPa) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA953Ra01 Recombinant Signal Regulatory Protein Alpha (SIRPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA953Ra01 Polyclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Signal Regulatory Protein Alpha (SIRPa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Regulatory Protein Alpha (SIRPa) ELISA Kit Customized Service Offer
  1. "Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal localization of genes."Biochem. Biophys. Res. Commun. 231:61-67(1997) [PubMed] [Europe PMC] [Abstract]
  2. "A family of proteins that inhibit signalling through tyrosine kinase receptors."Nature 386:181-186(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Gene structure of mouse BIT/SHPS-1."Biochem. J. 344:667-675(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  8. "SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages."Curr. Biol. 9:927-930(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha."J. Biol. Chem. 275:28222-28229(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation."J. Immunol. 167:2547-2554(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "The structure of the macrophage signal regulatory protein alpha (SIRPalpha) inhibitory receptor reveals a binding face reminiscent of that used by T cell receptors."J. Biol. Chem. 282:14567-14575(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47."Mol. Cell 31:266-277(2008) [PubMed] [Europe PMC] [Abstract]