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Discoidin Domain Containing Receptor 2 (DDR2)

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CD167b; MIG20a; NTRKR3; TKT; TYRO10; Discoidin Domain Receptor Tyrosine Kinase 2; Neurotrophic tyrosine kinase, receptor-related 3; Receptor protein-tyrosine kinase TKT; Discoidin Domain Receptor Fami

Discoidin Domain Containing Receptor 2 (DDR2)
CCC A974
HGNC 2731
MGI 1345277
PubMed 22328973
RGD 619855
UniProt Q16832

In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions.

Discoidin domain receptor family, member 2 is a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA974Hu01 Recombinant Discoidin Domain Containing Receptor 2 (DDR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA974Hu01 Polyclonal Antibody to Discoidin Domain Containing Receptor 2 (DDR2) WB; ICC; IHC-P; IHC-F; ELISA.
MAA974Hu21 Monoclonal Antibody to Discoidin Domain Containing Receptor 2 (DDR2) WB; IHC; ICC; IP.
Assay Kits SEA974Hu ELISA Kit for Discoidin Domain Containing Receptor 2 (DDR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Discoidin Domain Containing Receptor 2 (DDR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Discoidin Domain Containing Receptor 2 (DDR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Discoidin Domain Containing Receptor 2 (DDR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Discoidin Domain Containing Receptor 2 (DDR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Discoidin Domain Containing Receptor 2 (DDR2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Discoidin Domain Containing Receptor 2 (DDR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Discoidin Domain Containing Receptor 2 (DDR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Discoidin Domain Containing Receptor 2 (DDR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Discoidin Domain Containing Receptor 2 (DDR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Discoidin Domain Containing Receptor 2 (DDR2) ELISA Kit Customized Service Offer
  1. "Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain."Oncogene 8:3433-3440(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The discoidin domain receptor tyrosine kinases are activated by collagen."Mol. Cell 1:13-23(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation."J. Biol. Chem. 280:39058-39066(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen."J. Biol. Chem. 280:40187-40194(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis."Arthritis Rheum. 56:2663-2673(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen."J. Biol. Chem. 283:6861-6868(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Transcriptional upregulation of DDR2 by ATF4 facilitates osteoblastic differentiation through p38 MAPK-mediated Runx2 activation."J. Bone Miner. Res. 25:2489-2503(2010) [PubMed] [Europe PMC] [Abstract]
  13. "An essential role of discoidin domain receptor 2 (DDR2) in osteoblast differentiation and chondrocyte maturation via modulation of Runx2 activation."J. Bone Miner. Res. 26:604-617(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Sensing extracellular matrix: an update on discoidin domain receptor function."Cell. Signal. 18:1108-1116(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Transmembrane collagen receptors."Annu. Rev. Cell Dev. Biol. 27:265-290(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Structural basis of the collagen-binding mode of discoidin domain receptor 2."EMBO J. 26:4168-4176(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Crystallographic insight into collagen recognition by discoidin domain receptor 2."Structure 17:1573-1581(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Somatic mutations of the protein kinase gene family in human lung cancer." Cancer Res. 65:7591-7595(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Mutations in DDR2 gene cause SMED with short limbs and abnormal calcifications."Am. J. Hum. Genet. 84:80-84(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients."Hum. Mol. Genet. 19:2239-2250(2010) [PubMed] [Europe PMC] [Abstract]