≡

Discoidin Domain Receptor Family, Member 1 (DDR1)

[Edit]

CD167a; CAK; DDR; EDDR1; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE; Cell adhesion kinase; Epithelial discoidin domain receptor 1; Mammary carcinoma kinase 10

Discoidin Domain Receptor Family, Member 1 (DDR1)
CCC A977
HGNC 2730
MGI 99216
PubMed 10783152
RGD 2252
UniProt Q08345
Wiki DDR1

DDR1 is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA977Hu01 Recombinant Discoidin Domain Receptor Family, Member 1 (DDR1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA977Hu02 Recombinant Discoidin Domain Receptor Family, Member 1 (DDR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA977Hu01 Polyclonal Antibody to Discoidin Domain Receptor Family, Member 1 (DDR1) WB; IHC; ICC; IP.
Assay Kits SEA977Hu ELISA Kit for Discoidin Domain Receptor Family, Member 1 (DDR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA977Mu01 Recombinant Discoidin Domain Receptor Family, Member 1 (DDR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA977Mu01 Polyclonal Antibody to Discoidin Domain Receptor Family, Member 1 (DDR1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Discoidin Domain Receptor Family, Member 1 (DDR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Discoidin Domain Receptor Family, Member 1 (DDR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Discoidin Domain Receptor Family, Member 1 (DDR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Discoidin Domain Receptor Family, Member 1 (DDR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Discoidin Domain Receptor Family, Member 1 (DDR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Discoidin Domain Receptor Family, Member 1 (DDR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Discoidin Domain Receptor Family, Member 1 (DDR1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues."J. Biol. Chem. 268:24290-24295(1993) [PubMed] [Europe PMC] [Abstract]
  2. "A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain."Proc. Natl. Acad. Sci. U.S.A. 90:5677-5681(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line."Cell Growth Differ. 5:1173-1183(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain."Oncogene 9:211-219(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Receptor protein tyrosine kinase DDR is up-regulated by p53 protein."FEBS Lett. 398:165-169(1996) [PubMed] [Europe PMC] [Abstract]
  6. "The genomic structure of discoidin receptor tyrosine kinase."Genome Res. 6:620-627(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines."Oncogene 12:1469-1477(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."Arthritis Res. Ther. 10:R73-R73(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity." Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
  11. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Glycosylation at Asn211 regulates the activation state of the discoidin domain receptor 1 (DDR1)."J. Biol. Chem. 289:9275-9287(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer."Oncogene 10:609-618(1995) [PubMed] [Europe PMC] [Abstract]
  15. "Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors."Ann. Surg. Oncol. 1:18-27(1994) [PubMed] [Europe PMC] [Abstract]
  16. "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes."Oncogene 8:3403-3410(1993) [PubMed] [Europe PMC] [Abstract]
  17. "The discoidin domain receptor tyrosine kinases are activated by collagen."Mol. Cell 1:13-23(1997) [PubMed] [Europe PMC] [Abstract]
  18. "Tyrosine kinase activity of discoidin domain receptor 1 is necessary for smooth muscle cell migration and matrix metalloproteinase expression."Circ. Res. 90:1147-1149(2002) [PubMed] [Europe PMC] [Abstract]
  19. "Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1."FEBS Lett. 580:15-22(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2."J. Neurooncol. 76:239-248(2006) [PubMed] [Europe PMC] [Abstract]
  21. "KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling."Biochim. Biophys. Acta 1783:383-393(2008) [PubMed] [Europe PMC] [Abstract]
  22. "The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA."J. Cell Sci. 122:1637-1646(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  24. "DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation."J. Cell. Physiol. 224:387-397(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through Src."Cardiovasc. Pathol. 20:71-76(2011) [PubMed] [Europe PMC] [Abstract]
  26. "Discoidin domain receptor 1 regulates bronchial epithelial repair and matrix metalloproteinase production."Eur. Respir. J. 37:1482-1493(2011) [PubMed] [Europe PMC] [Abstract]
  27. "Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1."Matrix Biol. 30:16-26(2011) [PubMed] [Europe PMC] [Abstract]
  28. "Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory Fab fragment reveals features important for signaling."Structure 20:688-697(2012) [PubMed] [Europe PMC] [Abstract]
  29. "Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor."ACS Chem. Biol. 8:2145-2150(2013) [PubMed] [Europe PMC] [Abstract]
  30. "Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors."J. Mol. Biol. 426:2457-2470(2014) [PubMed] [Europe PMC] [Abstract]
  31. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]