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Cluster Of Differentiation 161 (CD161)

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KLRB1; KLR-B1; CLEC5B; NKR; NKR-P1; NKR-P1A; NKRP1A; HNKR-P1A; Killer Cell Lectin Like Receptor Subfamily B, Member 1; C-type lectin domain family 5 member B; Natural killer cell surface protein P1A

Cluster Of Differentiation 161 (CD161)
CCC A986
HGNC 6373
MGI 107539
PubMed 18159636
UniProt Q12918
Wiki KLRB1

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function.

The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or D161, is classified as a type II membrane protein because it has an external C terminus. NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA986Hu01 Recombinant Cluster Of Differentiation 161 (CD161) Positive Control; Immunogen; SDS-PAGE; WB.
RPA986Hu02 Recombinant Cluster Of Differentiation 161 (CD161) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA986Hu01 Polyclonal Antibody to Cluster Of Differentiation 161 (CD161) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 161 (CD161) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 161 (CD161) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cluster Of Differentiation 161 (CD161) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 161 (CD161) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 161 (CD161) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 161 (CD161) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 161 (CD161) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA986Ra01 Recombinant Cluster Of Differentiation 161 (CD161) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 161 (CD161) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 161 (CD161) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 161 (CD161) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 161 (CD161) ELISA Kit Customized Service Offer
  1. "Human NKR-P1A: a disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes."J. Immunol. 153:2417-2428(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "IL-12-induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A-mediated down-regulation of NK cell activation."Eur. J. Immunol. 28:1611-1616(1998) [PubMed] [Europe PMC] [Abstract]
  4. "CD161+ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver."Clin. Exp. Immunol. 129:92-98(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Lectin-like transcript 1 is a ligand for the CD161 receptor."J. Immunol. 175:7791-7795(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor."J. Immunol. 175:7796-7799(2005) [PubMed] [Europe PMC] [Abstract]
  7. "CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase."J. Immunol. 176:2397-2406(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161)."Xenotransplantation 13:440-446(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of alternatively spliced transcript variants of CLEC2D gene."J. Biol. Chem. 285:36207-36215(2010) [PubMed] [Europe PMC] [Abstract]