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Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1)

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CD305; hLAIR1

Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1)
CCC B004
HGNC 6477
MGI 105492
PubMed 9285412
RGD 1560048
UniProt Q6GTX8
Wiki LAIR1

LAIR1 is a type I membrane protein with a leader sequence, an extracellular domain, a transmembrane domain, and a cytoplasmic region. LAIR-1 is a 32 kDa transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell-mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, LAIR-1 does not appear to recognize human leukocyte antigen (HLA) class I molecules and thus represents a novel HLA class I-independent mechanism of NK cell regulation.

 

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB004Hu01 Recombinant Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB004Hu01 Polyclonal Antibody to Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) WB; IHC; ICC; IP.
MAB004Hu21 Monoclonal Antibody to Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) WB; IHC; ICC; IP.
Assay Kits SEB004Hu ELISA Kit for Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB004Mu01 Recombinant Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAB004Mu21 Monoclonal Antibody to Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) WB; IHC; ICC; IP.
MAB004Mu22 Monoclonal Antibody to Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) WB; IHC; ICC; IP.
MAB004Mu23 Monoclonal Antibody to Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) WB; IHC; ICC; IP.
MAB004Mu24 Monoclonal Antibody to Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB004Ra01 Recombinant Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAB004Ra22 Monoclonal Antibody to Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) WB; IHC; ICC; IP.
MAB004Ra21 Monoclonal Antibody to Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) ELISA Kit Customized Service Offer
  1. "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes."Immunity 7:283-290(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells."J. Immunol. 162:5800-5804(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells."J. Biol. Chem. 275:17440-17446(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor."Eur. J. Immunol. 28:2086-2091(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling."Eur. J. Immunol. 29:3160-3167(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias."Eur. J. Immunol. 30:2751-2758(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells."J. Immunol. 166:1763-1770(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell functions."Hum. Immunol. 63:534-546(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment."Int. Immunol. 15:1349-1358(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells."J. Clin. Immunol. 23:141-145(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection."Blood 103:2180-2186(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Inhibitory receptors CD85j, LAIR-1, and CD152 down-regulate immunoglobulin and cytokine production by human B lymphocytes."Clin. Diagn. Lab. Immunol. 12:705-712(2005) [PubMed] [Europe PMC] [Abstract]
  14. "The inhibitory leukocyte-associated Ig-like receptor-1 (LAIR-1) is expressed at high levels by human naive T cells and inhibits TCR mediated activation."Mol. Immunol. 42:1521-1530(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Leukocyte-associated Ig-like receptor-1 has SH2 domain-containing phosphatase-independent function and recruits C-terminal Src kinase."Eur. J. Immunol. 36:190-198(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI."Blood 115:1364-1373(2010) [PubMed] [Europe PMC] [Abstract]