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Cluster Of Differentiation 320 (CD320)

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8D6; 8D6A; CD320 Antigen; TCblR; FDC-signaling molecule 8D6; Transcobalamin receptor

Cluster Of Differentiation 320 (CD320)
CCC B007
HGNC 16692
MGI 1860083
PubMed 20524213
RGD 1305860
UniProt Q9NPF0
Wiki CD320

Transcobalamin II (TCN2), a plasma protein secreted by endothelial cells, binds the cobalamin absorbed in the distal ileum and carries 10 to 30% of total circulating cobalamin. CD320 encodes a transcobalamin receptor that binds TCN2-cobalamin at the plasma membrane and internalizes the complex by endocytosis .Functional analysis by Li et al. (2000) indicated that expression of 8D6 enhanced B-cell proliferation and immunoglobulin secretion. Treatment of the FDC cell line and a lymphoma cell line coculture with anti-8D6 resulted in at least partial inhibition of lymphoma growth. Li et al. (2000) proposed that antagonists of the 8D6 signaling pathway may counter the growth of follicular lymphomas or other tumors that metastasize to lymphoid follicles.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins CPB007Hu21 OVA Conjugated Cluster Of Differentiation 320 (CD320) Immunogen; SDS-PAGE; WB.
RPB007Hu01 Recombinant Cluster Of Differentiation 320 (CD320) Positive Control; Immunogen; SDS-PAGE; WB.
APB007Hu01 Active Cluster Of Differentiation 320 (CD320) Cell culture; Activity Assays.
Antibodies PAB007Mi08 Polyclonal Antibody to Cluster Of Differentiation 320 (CD320) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 320 (CD320) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 320 (CD320) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB007Mu01 Recombinant Cluster Of Differentiation 320 (CD320) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 320 (CD320) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 320 (CD320) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 320 (CD320) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 320 (CD320) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB007Ra01 Recombinant Cluster Of Differentiation 320 (CD320) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB007Ra01 Polyclonal Antibody to Cluster Of Differentiation 320 (CD320) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 320 (CD320) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 320 (CD320) ELISA Kit Customized Service Offer
  1. "Identification of a human follicular dendritic cell molecule that stimulates germinal center B cell growth."J. Exp. Med. 191:1077-1084(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The distinct roles of T cell-derived cytokines and a novel follicular dendritic cell-signaling molecule 8D6 in germinal center-B cell differentiation."J. Immunol. 167:49-56(2001) [PubMed] [Europe PMC] [Abstract]
  9. "The protein and the gene encoding the receptor for the cellular uptake of transcobalamin-bound cobalamin."Blood 113:186-192(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Positive newborn screen for methylmalonic aciduria identifies the first mutation in TCblR/CD320, the gene for cellular uptake of transcobalamin-bound vitamin B(12)."Hum. Mutat. 31:924-929(2010) [PubMed] [Europe PMC] [Abstract]