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Integrin Associated Protein (IAP)

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CD47; MER6; OA3; Antigen Identified By Monoclonal Antibody 1D8; Antigenic Surface Determinant Protein OA3; Rh-Related Antigen

Integrin Associated Protein (IAP)
CCC B014
HGNC 1682
MGI 96617
PubMed 11306274
RGD 2308
UniProt Q08722
Wiki CD47

CD47  is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Isoform 2 and 4 are the most abundant. Other than thrombospondin, CD47 also binds CD172a. CD47 deficient mice have been generated. Their reported phenotype is a defect in cellular migration of the CD172a expressing cells, suggesting that CD47 to CD172a interactions are necessary for the proper distribution of these cell types.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB014Hu01 Recombinant Integrin Associated Protein (IAP) Positive Control; Immunogen; SDS-PAGE; WB.
CPB014Hu21 OVA Conjugated Integrin Associated Protein (IAP) Immunogen; SDS-PAGE; WB.
Antibodies PAB014Hu01 Polyclonal Antibody to Integrin Associated Protein (IAP) WB; IHC; ICC; IP.
MAB014Hu22 Monoclonal Antibody to Integrin Associated Protein (IAP) WB; IHC; ICC; IP.
Assay Kits SEB014Hu ELISA Kit for Integrin Associated Protein (IAP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB014Mu01 Recombinant Integrin Associated Protein (IAP) Positive Control; Immunogen; SDS-PAGE; WB.
APB014Mu01 Active Integrin Associated Protein (IAP) Cell culture; Activity Assays.
Antibodies PAB014Mu01 Polyclonal Antibody to Integrin Associated Protein (IAP) WB; IHC; ICC; IP.
Assay Kits SEB014Mu ELISA Kit for Integrin Associated Protein (IAP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrin Associated Protein (IAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrin Associated Protein (IAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrin Associated Protein (IAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrin Associated Protein (IAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Associated Protein (IAP) ELISA Kit Customized Service Offer
  1. "An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains."Cancer Res. 52:5416-5420(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane spanning domains implicated in alpha-v beta-3-dependent ligand binding."J. Cell Biol. 123:485-496(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3."Biochem. J. 304:525-530(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane."Mol. Cell 4:619-625(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains."J. Biol. Chem. 276:34607-34616(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation."J. Immunol. 167:2547-2554(2001) [PubMed] [Europe PMC] [Abstract]
  9. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation."Blood 105:2421-2427(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47."Mol. Cell 31:266-277(2008) [PubMed] [Europe PMC] [Abstract]