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Alpha-1-Antichymotrypsin (a1ACT)

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A1-ACT; SERPINA3; AACT; ACT; GIG24; GIG25; Serpin Peptidase Inhibitor Clade A Member 3(Alpha-1 Antiproteinase; Antitrypsin); Cell growth-inhibiting gene 24/25 protein

Alpha-1-Antichymotrypsin (a1ACT)
CCC B015
HGNC 16
MGI 105045
PubMed 9822922
RGD 3747
UniProt P01011
Wiki A1ACT

Alpha 1-antichymotrypsin is an alpha globulin glycoprotein that is a member of the serine proteinase inhibitor (serpin) family.It inhibits the activity of certain enzymes called proteinases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes.

This enzyme is produced in the liver, and is an acute phase protein that is induced during inflammation. Deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB015Hu01 Recombinant Alpha-1-Antichymotrypsin (a1ACT) Positive Control; Immunogen; SDS-PAGE; WB.
RPB015Hu02 Recombinant Alpha-1-Antichymotrypsin (a1ACT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB015Hu01 Polyclonal Antibody to Alpha-1-Antichymotrypsin (a1ACT) WB,IHC
MAB015Hu22 Monoclonal Antibody to Alpha-1-Antichymotrypsin (a1ACT) WB; IHC; ICC; IP.
Assay Kits SEB015Hu ELISA Kit for Alpha-1-Antichymotrypsin (a1ACT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB015Mu01 Recombinant Alpha-1-Antichymotrypsin (a1ACT) Positive Control; Immunogen; SDS-PAGE; WB.
RPB015Mu02 Recombinant Alpha-1-Antichymotrypsin (a1ACT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB015Mu01 Polyclonal Antibody to Alpha-1-Antichymotrypsin (a1ACT) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alpha-1-Antichymotrypsin (a1ACT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-1-Antichymotrypsin (a1ACT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alpha-1-Antichymotrypsin (a1ACT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alpha-1-Antichymotrypsin (a1ACT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alpha-1-Antichymotrypsin (a1ACT) Polyclonal Antibody Customized Service Offer
Assay Kits SEB015Ra ELISA Kit for Alpha-1-Antichymotrypsin (a1ACT) Enzyme-linked immunosorbent assay for Antigen Detection.
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  8. "Interactions of alpha-1-antichymotrypsin, alpha-1-proteinase inhibitor, and alpha-2-macroglobulin with the fungal enzyme, seaprose."Biol. Chem. Hoppe-Seyler 375:335-341(1994) [PubMed] [Europe PMC] [Abstract]
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  10. "Characterisation of the tumour-associated carbohydrate epitope recognised by monoclonal antibody 4D3."Int. J. Cancer 66:636-644(1996) [PubMed] [Europe PMC] [Abstract]
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  12. "Plasma protease inhibitors in mouse and man: divergence within the reactive centre regions."Nature 311:175-177(1984) [PubMed] [Europe PMC] [Abstract]
  13. "Amino acid sequence at the reactive site of human alpha 1-antichymotrypsin."J. Biol. Chem. 258:12749-12752(1983) [PubMed] [Europe PMC] [Abstract]
  14. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
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  16. "Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus."J. Mol. Evol. 59:488-497(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  20. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
  21. "Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7-A resolution and its comparison with other serpins."J. Mol. Biol. 218:595-606(1991) [PubMed] [Europe PMC] [Abstract]
  22. "Arginine substitutions in the hinge region of antichymotrypsin affect serpin beta-sheet rearrangement."Nat. Struct. Biol. 3:888-893(1996) [PubMed] [Europe PMC] [Abstract]
  23. "Engineering an anion-binding cavity in antichymotrypsin modulates the 'spring-loaded' serpin-protease interaction."Biochemistry 37:3297-3304(1998) [PubMed] [Europe PMC] [Abstract]
  24. "Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease."Proc. Natl. Acad. Sci. U.S.A. 97:67-72(2000) [PubMed] [Europe PMC] [Abstract]
  25. "Detection of a new mutant alpha-1-antichymotrypsin in patients with occlusive-cerebrovascular disease."FEBS Lett. 304:66-68(1992) [PubMed] [Europe PMC] [Abstract]
  26. "Mis-sense mutation of alpha 1-antichymotrypsin gene associated with chronic lung disease."Lancet 339:1538-1538(1992) [PubMed] [Europe PMC] [Abstract]
  27. "Alpha-1-antichymotrypsin gene A1252G variant (ACT Isehara-1) is associated with a lacunar type of ischemic cerebrovascular disease."J. Hum. Genet. 46:45-47(2001) [PubMed] [Europe PMC] [Abstract]