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Protein Tyrosine Phosphatase Receptor Type C (CD45)

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PTPRC; PTPR-C; LCA; B220; GP180; LY5; T200; Leukocyte common antigen

Protein Tyrosine Phosphatase Receptor Type C (CD45)
CCC B030
HGNC 9666
MGI 97810
PubMed 11528386
RGD 3451
UniProt P08575
Wiki PTPRC

PTPRC is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP.

PTPRC is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB030Hu01 Recombinant Protein Tyrosine Phosphatase Receptor Type C (CD45) Positive Control; Immunogen; SDS-PAGE; WB.
RPB030Hu02 Recombinant Protein Tyrosine Phosphatase Receptor Type C (CD45) Positive Control; Immunogen; SDS-PAGE; WB.
EPB030Hu61 Eukaryotic Protein Tyrosine Phosphatase Receptor Type C (CD45) Positive Control; Immunogen; SDS-PAGE; WB.
RPB030Hu03 Recombinant Protein Tyrosine Phosphatase Receptor Type C (CD45) Positive Control; Immunogen; SDS-PAGE; WB.
APB030Hu61 Active Protein Tyrosine Phosphatase Receptor Type C (CD45) Cell culture; Activity Assays.
Antibodies PAB030Hu01 Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type C (CD45) WB; IHC; ICC; IP.
PAB030Hu02 Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type C (CD45) WB; IHC; ICC; IP.
MAB030Hu22 Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type C (CD45) WB; IHC; ICC; IP.
LAB030Hu71 Biotin-Linked Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type C (CD45) WB; IHC; ICC.
MAB030Hu21 Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type C (CD45) WB; IHC; ICC; IP.
MAB030Hu23 Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type C (CD45) WB; IHC; ICC; IP.
MAB030Hu24 Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type C (CD45) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase Receptor Type C (CD45) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase Receptor Type C (CD45) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB030Mu01 Recombinant Protein Tyrosine Phosphatase Receptor Type C (CD45) Positive Control; Immunogen; SDS-PAGE; WB.
RPB030Mu02 Recombinant Protein Tyrosine Phosphatase Receptor Type C (CD45) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB030Mu01 Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type C (CD45) WB; IHC; ICC; IP.
PAB030Mu02 Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type C (CD45) WB; IHC; ICC; IP.
LAB030Mu71 Biotin-Linked Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type C (CD45) WB; IHC; ICC.
Assay Kits SEB030Mu ELISA Kit for Protein Tyrosine Phosphatase Receptor Type C (CD45) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB030Ra01 Recombinant Protein Tyrosine Phosphatase Receptor Type C (CD45) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB030Ra01 Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type C (CD45) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase Receptor Type C (CD45) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase Receptor Type C (CD45) ELISA Kit Customized Service Offer
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  2. "Structural variants of human T200 glycoprotein (leukocyte-common antigen)."EMBO J. 6:1251-1257(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Integrity of the exon 6 sequence is essential for tissue-specific alternative splicing of human leukocyte common antigen pre-mRNA."Mol. Cell. Biol. 9:4550-4555(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Complete exon-intron organization of the human leukocyte common antigen (CD45) gene."J. Immunol. 141:2781-2787(1988) [PubMed] [Europe PMC] [Abstract]
  6. "The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase."Proc. Natl. Acad. Sci. U.S.A. 85:7182-7186(1988) [PubMed] [Europe PMC] [Abstract]
  7. "Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR."EMBO J. 9:2399-2407(1990) [PubMed] [Europe PMC] [Abstract]
  8. "SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription."Mol. Cell. Biol. 22:2673-2686(2002) [PubMed] [Europe PMC] [Abstract]
  9. "A role for interleukin-12 in the regulation of T cell plasma membrane compartmentation."J. Biol. Chem. 278:24849-24857(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells."PLoS Pathog. 7:E1002432-E1002432(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45."J. Exp. Med. 201:441-452(2005) [PubMed] [Europe PMC] [Abstract]
  17. "A point mutation in PTPRC is associated with the development of multiple sclerosis."Nat. Genet. 26:495-499(2000) [PubMed] [Europe PMC] [Abstract]
  18. "A deletion in the gene encoding the CD45 antigen in a patient with SCID."J. Immunol. 166:1308-1313(2001) [PubMed] [Europe PMC] [Abstract]
  19. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]