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Polymeric Immunoglobulin Receptor (PIGR)

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SC; Secretory Component; Hepatocellular carcinoma-associated protein TB6

Polymeric Immunoglobulin Receptor (PIGR)
CCC B074
HGNC 8968
MGI 103080
PubMed 23809084
RGD 3328
UniProt P01833
Wiki PIGR

Polymeric immunoglobulin receptor is a Fc receptor which facilitates the secretion of IgA and IgM. The poly-Ig receptor is expressed on several glandular epithelia including those of liver and breast. It mediates transcellular transport of polymeric immunoglobulin molecules.

It is a member of the immunoglobulin superfamily (Hood et al., 1985). The receptor has 5 units with homology to the variable (V) units of immunoglobulins and a transmembrane region, which also has some homology to certain immunoglobulin variable regions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB074Hu01 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB074Hu02 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB074Hu01 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC; IP.
MAB074Hu22 Monoclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC; IP.
PAB074Hu02 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC; IP.
LAB074Hu71 Biotin-Linked Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC.
Assay Kits SEB074Hu ELISA Kit for Polymeric Immunoglobulin Receptor (PIGR) Enzyme-linked immunosorbent assay for Antigen Detection.
AEB074Hu ELISA Kit for Anti-Polymeric Immunoglobulin Receptor Antibody (Anti-PIGR) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB074Mu01 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB074Mu03 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB074Mu02 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB074Mu01 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC; IP.
PAB074Mu02 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC; IP.
PAB074Mu03 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC; IP.
LAB074Mu71 Biotin-Linked Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC.
Assay Kits SEB074Mu ELISA Kit for Polymeric Immunoglobulin Receptor (PIGR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB074Ra01 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB074Ra02 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB074Ra03 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB074Ra01 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC; IP.
PAB074Ra02 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC; IP.
LAB074Ra71 Biotin-Linked Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC.
PAB074Ra03 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Polymeric Immunoglobulin Receptor (PIGR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polymeric Immunoglobulin Receptor (PIGR) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB074Bo01 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB074Bo03 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB074Bo02 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB074Bo01 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC; IP.
PAB074Bo02 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC; IP.
PAB074Bo03 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC; IP.
LAB074Bo71 Biotin-Linked Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC.
Assay Kits SEB074Bo ELISA Kit for Polymeric Immunoglobulin Receptor (PIGR) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The human transmembrane secretory component (poly-Ig receptor): molecular cloning, restriction fragment length polymorphism and chromosomal sublocalization."Hum. Genet. 87:642-648(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor)."Eur. J. Immunol. 22:2309-2315(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning of the human transmembrane secretory component (poly-Ig receptor) and its mRNA expression in human tissues."Biochem. Biophys. Res. Commun. 158:783-789(1989) [PubMed] [Europe PMC] [Abstract]
  5. "The primary structure of human free secretory component and the arrangement of disulfide bonds."Hoppe-Seyler's Z. Physiol. Chem. 365:1489-1495(1984) [PubMed] [Europe PMC] [Abstract]
  6. "Determination of the molecular structure of the human free secretory component."Biol. Chem. Hoppe-Seyler 372:119-128(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Human free secretory component is composed of the first 585 amino acid residues of the polymeric immunoglobulin receptor."FEBS Lett. 410:443-446(1997) [PubMed] [Europe PMC] [Abstract]
  8. "A proteomic analysis of human bile."Mol. Cell. Proteomics 3:715-728(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  13. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor."Structure 12:1925-1935(2004) [PubMed] [Europe PMC] [Abstract]