Bone Sialoprotein (BSP)
[Edit]IBSP; Bsp; BspII; SpII; Integrin-Binding Bone Sialoprotein; Cell-binding sialoprotein; Bone sialoprotein 2
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Bone sialoprotein (BSP) is a component of mineralized tissues such as bone, dentin, cementum and calcified cartilage. BSP is a significant component of the bone extracellular matrix and has been suggested to constitute approximately 8% of all non-collagenous proteins found in bone and cementum. BSP was originally isolated from bovine cortical bone as a 23-kDa glycopeptide with high sialic acid content, as described in separate reports by Williams and Peacocke and Andrews and Herring Native BSP has an apparent molecular weight of 60-80 kDa based on SDS-PAGE, which is a considerable deviation from the predicted weight of approximately 33 kDa. The mammalian BSP cDNAs encode for proteins averaging 327 amino acids,, which includes the 16-residue preprotein secretory signal peptide.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB092Hu01 | Recombinant Bone Sialoprotein (BSP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| EPB092Hu61 | Eukaryotic Bone Sialoprotein (BSP) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| EPB092Hu62 | Eukaryotic Bone Sialoprotein (BSP) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APB092Hu61 | Active Bone Sialoprotein (BSP) | Cell culture; Activity Assays. | |
| Antibodies | PAB092Hu01 | Polyclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IP. |
| MAB092Hu22 | Monoclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB092Hu | ELISA Kit for Bone Sialoprotein (BSP) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB092Mu01 | Recombinant Bone Sialoprotein (BSP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB092Mu02 | Recombinant Bone Sialoprotein (BSP) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| EPB092Mu61 | Eukaryotic Bone Sialoprotein (BSP) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB092Mu01 | Polyclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IP. |
| PAB092Mu02 | Polyclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB092Mu | ELISA Kit for Bone Sialoprotein (BSP) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Bone Sialoprotein (BSP) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Bone Sialoprotein (BSP) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Bone Sialoprotein (BSP) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Bone Sialoprotein (BSP) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Bone Sialoprotein (BSP) | ELISA Kit Customized Service Offer |
- "Human bone sialoprotein. Deduced protein sequence and chromosomal localization."J. Biol. Chem. 265:2347-2351(1990) [PubMed] [Europe PMC] [Abstract]
- "The human bone sialoprotein gene (IBSP): genomic localization and characterization."Genomics 17:408-415(1993) [PubMed] [Europe PMC] [Abstract]
- "Characterization of the human bone sialoprotein (BSP) gene and its promoter sequence."Matrix Biol. 14:31-40(1994) [PubMed] [Europe PMC] [Abstract]
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
- "Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone."J. Biol. Chem. 262:9702-9708(1987) [PubMed] [Europe PMC] [Abstract]
- "Structural characterization of human recombinant and bone-derived bone sialoprotein. Functional implications for cell attachment and hydroxyapatite binding."J. Biol. Chem. 276:36839-36848(2001) [PubMed] [Europe PMC] [Abstract]
- "Posttranslational modifications to human bone sialoprotein determined by mass spectrometry."Biochemistry 40:12983-12991(2001) [PubMed] [Europe PMC] [Abstract]