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Nucleoporin 50kDa (NUP50)

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NPAP60; NPAP60L; Nuclear pore-associated protein 60 kDa-like

Nucleoporin 50kDa (NUP50)
CCC B101
HGNC 8065
MGI 1351502
PubMed 10891499
UniProt Q9UKX7
Wiki NUP50

Nucleoporin 50 kDa is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. NUP50 is a tristable switch that alternates between binding modes.

The C terminus binds importin-beta through RAN-GTP. The N terminus binds the C terminus of importin-alpha, while a central domain binds importin-beta. NUP50:importin-alpha:importin-beta binds cargo and can stimulate nuclear import. Endogenous NUP50 can shuttle and is accessible from the cytoplasmic side of the nuclear envelope. These findings identified NUP50 as a cofactor for importin-alpha:importin-beta nuclear import and as a subunit of the importin complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB101Hu01 Recombinant Nucleoporin 50kDa (NUP50) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB101Hu01 Polyclonal Antibody to Nucleoporin 50kDa (NUP50) WB; IHC; ICC/IF
Assay Kits n/a CLIA Kit for Nucleoporin 50kDa (NUP50) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoporin 50kDa (NUP50) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB101Mu01 Recombinant Nucleoporin 50kDa (NUP50) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB101Mu01 Polyclonal Antibody to Nucleoporin 50kDa (NUP50) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nucleoporin 50kDa (NUP50) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoporin 50kDa (NUP50) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB101Ra01 Recombinant Nucleoporin 50kDa (NUP50) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB101Ra01 Polyclonal Antibody to Nucleoporin 50kDa (NUP50) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nucleoporin 50kDa (NUP50) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoporin 50kDa (NUP50) ELISA Kit Customized Service Offer
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