≡

Cluster Of Differentiation 42b (CD42b)

[Edit]

GP1Ba; CD42-B; CD42b-Alpha; GP1-BA; BSS; GP1B; GPIBA; Glycocalicin; Glycoprotein Ib Alpha Polypeptide, Platelet

Cluster Of Differentiation 42b (CD42b)
CCC B108
HGNC 4439
MGI 1333744
PubMed 24474090
RGD 1310239
UniProt P07359
Wiki GP1BA

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB108Hu01 Recombinant Cluster Of Differentiation 42b (CD42b) Positive Control; Immunogen; SDS-PAGE; WB.
EPB108Hu61 Eukaryotic Cluster Of Differentiation 42b (CD42b) Positive Control; Immunogen; SDS-PAGE; WB.
APB108Hu61 Active Cluster Of Differentiation 42b (CD42b) Cell culture; Activity Assays.
Antibodies PAB108Hu01 Polyclonal Antibody to Cluster Of Differentiation 42b (CD42b) WB; IHC; ICC; IP.
MAB108Hu21 Monoclonal Antibody to Cluster Of Differentiation 42b (CD42b) WB; IHC; ICC; IP.
Assay Kits SEB108Hu ELISA Kit for Cluster Of Differentiation 42b (CD42b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB108Mu01 Recombinant Cluster Of Differentiation 42b (CD42b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB108Mu01 Polyclonal Antibody to Cluster Of Differentiation 42b (CD42b) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 42b (CD42b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 42b (CD42b) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cluster Of Differentiation 42b (CD42b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 42b (CD42b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 42b (CD42b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 42b (CD42b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 42b (CD42b) ELISA Kit Customized Service Offer
  1. "Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein."Proc. Natl. Acad. Sci. U.S.A. 84:5615-5619(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of the human blood platelet membrane glycoprotein Ib alpha gene."Biochem. Biophys. Res. Commun. 156:389-395(1988) [PubMed] [Europe PMC] [Abstract]
  3. "A novel polymorphism, 70Leu/Phe, disrupts a consensus Leu residue within the leucine-rich repeat sequence of platelet glycoprotein Ibalpha."Thromb. Haemost. 87:867-872(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of a novel point mutation in platelet glycoprotein Ibalpha, Gly to Ser at residue 233, in a Japanese family with platelet-type von Willebrand disease."J. Thromb. Haemost. 1:2198-2205(2003) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib."Proc. Natl. Acad. Sci. U.S.A. 84:5610-5614(1987) [PubMed] [Europe PMC] [Abstract]
  8. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  9. "StyI polymorphism at nucleotide 1610 in the human platelet glycoprotein Ib alpha gene."Jpn. J. Hum. Genet. 41:419-421(1996) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of the disulphide bonds in human platelet glycocalicin."Eur. J. Biochem. 199:389-393(1991) [PubMed] [Europe PMC] [Abstract]
  11. "Human beta-filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha."J. Biol. Chem. 273:17531-17538(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting platelet."Blood 109:603-609(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structure of the platelet glycoprotein Ibalpha N-terminal domain reveals an unmasking mechanism for receptor activation."J. Biol. Chem. 277:35657-35663(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain."Science 297:1176-1179(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Molecular modeling of the seven tandem leucine-rich repeats within the ligand-binding region of platelet glycoprotein Ib alpha."Thromb. Haemost. 87:329-333(2002) [PubMed] [Europe PMC] [Abstract]
  18. "Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness."Blood 79:3086-3090(1992) [PubMed] [Europe PMC] [Abstract]
  19. "Mutation of leucine-57 to phenylalanine in a platelet glycoprotein Ib alpha leucine tandem repeat occurring in patients with an autosomal dominant variant of Bernard-Soulier disease."Blood 79:439-446(1992) [PubMed] [Europe PMC] [Abstract]
  20. "Polymorphism of human glycoprotein Ib alpha results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region. Structure/function implications."J. Biol. Chem. 267:10055-10061(1992) [PubMed] [Europe PMC] [Abstract]
  21. "Point mutation in a leucine-rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard-Soulier syndrome."J. Clin. Invest. 92:1213-1220(1993) [PubMed] [Europe PMC] [Abstract]
  22. "Cys209 Ser mutation in the platelet membrane glycoprotein Ib alpha gene is associated with Bernard-Soulier syndrome."Br. J. Haematol. 88:839-844(1994) [PubMed] [Europe PMC] [Abstract]
  23. "Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease."Proc. Natl. Acad. Sci. U.S.A. 88:4761-4765(1991) [PubMed] [Europe PMC] [Abstract]
  24. "Expression of the phenotypic abnormality of platelet-type von Willebrand disease in a recombinant glycoprotein Ib alpha fragment."J. Clin. Invest. 91:2133-2137(1993) [PubMed] [Europe PMC] [Abstract]
  25. "Pseudo-von Willebrand disease: a mutation in the platelet glycoprotein Ib alpha gene associated with a hyperactive surface receptor."Blood 81:1787-1791(1993) [PubMed] [Europe PMC] [Abstract]
  26. "The largest variant of platelet glycoprotein Ib alpha has four tandem repeats of 13 amino acids in the macroglycopeptide region and a genetic linkage with methionine145."Blood 86:1357-1360(1995) [PubMed] [Europe PMC] [Abstract]
  27. "A three-base deletion removing a leucine residue in a leucine-rich repeat of platelet glycoprotein Ib alpha associated with a variant of Bernard-Soulier syndrome (Nancy I)."Br. J. Haematol. 89:386-396(1995) [PubMed] [Europe PMC] [Abstract]
  28. "Naturally occurring mutations in glycoprotein Ibalpha that result in defective ligand binding and synthesis of a truncated protein."Blood 92:175-183(1998) [PubMed] [Europe PMC] [Abstract]
  29. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  30. ErratumNat. Genet. 23:373-373(1999)
  31. "Molecular characterization of two mutations in platelet glycoprotein (GP) Ib alpha in two Finnish Bernard-Soulier syndrome families."Eur. J. Haematol. 62:160-168(1999) [PubMed] [Europe PMC] [Abstract]
  32. "Autosomal dominant macrothrombocytopenia in Italy is most frequently a type of heterozygous Bernard-Soulier syndrome."Blood 97:1330-1335(2001) [PubMed] [Europe PMC] [Abstract]
  33. "Nonarteritic anterior ischemic optic neuropathy is associated with a specific platelet polymorphism located on the glycoprotein Ibalpha gene."Ophthalmology 111:184-188(2004) [PubMed] [Europe PMC] [Abstract]