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Nucleoporin 85 (NUP85)

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Nup75; FROUNT; Nuclear pore complex protein Nup85; Pericentrin-1; Nucleoporin 85kDa

Nucleoporin 85 (NUP85)
CCC B110
HGNC 8734
MGI 3046173
PubMed 10454574
RGD 1311942
UniProt Q9BW27
Wiki NUP85

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such subcomplex, Nup107-160.

By proteomic analysis and mass spectrometry, Cronshaw et al. (2002) identified 94 proteins associated with NPCs purified from rat liver nuclei. Database analysis identified FLJ12549, which Cronshaw et al. (2002) called NUP75, as the human homolog of a rat protein found in relative abundance, with 16 copies per NPC. The deduced human protein has a calculated molecular mass of 75 kD and is homologous to the yeast Nup85 protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB110Hu01 Recombinant Nucleoporin 85 (NUP85) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB110Hu01 Polyclonal Antibody to Nucleoporin 85 (NUP85) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nucleoporin 85 (NUP85) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoporin 85 (NUP85) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB110Mu01 Recombinant Nucleoporin 85 (NUP85) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB110Mu01 Polyclonal Antibody to Nucleoporin 85 (NUP85) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nucleoporin 85 (NUP85) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoporin 85 (NUP85) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleoporin 85 (NUP85) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleoporin 85 (NUP85) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleoporin 85 (NUP85) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleoporin 85 (NUP85) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoporin 85 (NUP85) ELISA Kit Customized Service Offer
  1. "Proteomic analysis of the mammalian nuclear pore complex."J. Cell Biol. 158:915-927(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis."Nat. Immunol. 6:827-835(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Removal of a single pore subcomplex results in vertebrate nuclei devoid of nuclear pores."Mol. Cell 11:853-864(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis."Mol. Biol. Cell 15:3333-3344(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly."Mol. Biol. Cell 17:3806-3818(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]