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Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1)

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SMD1; SNRP-D1; Sm-D autoantigen; snRNP core protein D1

Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1)
CCC B128
HGNC 11158
MGI 98344
RGD 1306345
UniProt P62314

Small nuclear ribonucleoprotein Sm D1 is a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA.A clone was obtained that encoded a predicted 357-amino acid protein with 9 Gly-Arg repeats at its carboxy terminus similar to regions in the Epstein-Barr virus nuclear proteins EBNA-1 and EBNA-2, as well as the yeast transcription factor SNF2 .Lehmeier et al. (1994) showed that the D1 amino acid sequence is 29% identical to D3 and less than 15% identical to D2. The authors also showed that sera from 3 patients with lupus erythematosus detected the D1 and D3 components twice and the D2 component 3 times.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB128Hu01 Recombinant Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB128Hu01 Polyclonal Antibody to Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1) WB,IHC
Assay Kits n/a CLIA Kit for Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a cDNA encoding the human Sm-D autoantigen."Proc. Natl. Acad. Sci. U.S.A. 85:4832-4836(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of the major human ribonucleoprotein (RNP) autoantigens in Escherichia coli and their use in an EIA for screening sera from patients with autoimmune diseases."Clin. Chem. 35:1861-1863(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln."Curr. Biol. 11:1990-1994(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
  7. "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome."RNA 10:929-941(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins."J. Cell Biol. 178:733-740(2007) [PubMed] [Europe PMC] [Abstract]
  9. "An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs."Cell 135:497-509(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs."Cell 96:375-387(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution."Nature 458:475-480(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Functional organization of the Sm core in the crystal structure of human U1 snRNP."EMBO J. 29:4172-4184(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis."Nature 473:536-539(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Structural basis of assembly chaperone-mediated snRNP formation."Mol. Cell 49:692-703(2013) [PubMed] [Europe PMC] [Abstract]