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Structural Maintenance Of Chromosomes Protein 3 (SMC3)

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BMH; BAM; CSPG6; HCAP; SMC3L1; Chondroitin Sulfate Proteoglycan 6; Bamacan; Basement membrane-associated chondroitin proteoglycan; Chromosome-associated peptide

Structural Maintenance Of Chromosomes Protein 3 (SMC3)
CCC B146
HGNC 2468
MGI 1339795
PubMed 20832721
RGD 62006
UniProt Q9UQE7
Wiki SMC3
Structural maintenance of chromosomes 3 belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation.
Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB146Hu01 Recombinant Structural Maintenance Of Chromosomes Protein 3 (SMC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB146Hu01 Polyclonal Antibody to Structural Maintenance Of Chromosomes Protein 3 (SMC3) WB,IHC
LAB146Hu71 Biotin-Linked Polyclonal Antibody to Structural Maintenance Of Chromosomes Protein 3 (SMC3) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Structural Maintenance Of Chromosomes Protein 3 (SMC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Structural Maintenance Of Chromosomes Protein 3 (SMC3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Structural Maintenance Of Chromosomes Protein 3 (SMC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Structural Maintenance Of Chromosomes Protein 3 (SMC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Structural Maintenance Of Chromosomes Protein 3 (SMC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Structural Maintenance Of Chromosomes Protein 3 (SMC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Structural Maintenance Of Chromosomes Protein 3 (SMC3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Structural Maintenance Of Chromosomes Protein 3 (SMC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Structural Maintenance Of Chromosomes Protein 3 (SMC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Structural Maintenance Of Chromosomes Protein 3 (SMC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Structural Maintenance Of Chromosomes Protein 3 (SMC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Structural Maintenance Of Chromosomes Protein 3 (SMC3) ELISA Kit Customized Service Offer
  1. "Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide."J. Biol. Chem. 273:6591-6594(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of vertebrate cohesin complexes and their regulation in prophase."J. Cell Biol. 151:749-762(2000) [PubMed] [Europe PMC] [Abstract]
  6. "A potential role for human cohesin in mitotic spindle aster assembly."J. Biol. Chem. 276:47575-47582(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates."Mol. Cell 18:185-200(2005) [PubMed] [Europe PMC] [Abstract]
  8. ErratumMol. Cell 18:609-609(2005)
  9. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast."Mol. Cell 31:143-151(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Cohesin acetylation speeds the replication fork."Nature 462:231-234(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle." Nature 489:313-317(2012) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of Cornelia de Lange syndrome with predominant mental retardation."Am. J. Hum. Genet. 80:485-494(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Cornelia de Lange syndrome mutations in SMC1A or SMC3 affect binding to DNA."Hum. Mol. Genet. 18:418-427(2009) [PubMed] [Europe PMC] [Abstract]