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Caspase 10 (CASP10)

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ALPS2; FLICE2; MCH4; Apoptosis-Related Cysteine Peptidase; Cysteinyl Aspartate Specific Proteinases 10; FAS-associated death domain interleukin-1B-converting enzyme 2

Caspase 10 (CASP10)
CCC B161
HGNC 1500
PubMed 12010812
UniProt Q92851
Wiki Caspase_10

CASP10,a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme.

This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB161Hu01 Recombinant Caspase 10 (CASP10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB161Hu01 Polyclonal Antibody to Caspase 10 (CASP10) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Caspase 10 (CASP10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caspase 10 (CASP10) ELISA Kit Customized Service Offer
  1. "In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains."Proc. Natl. Acad. Sci. U.S.A. 93:7464-7469(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling."J. Biol. Chem. 272:6578-6583(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10."J. Biol. Chem. 274:10301-10308(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2."Genomics 71:200-213(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases."Proc. Natl. Acad. Sci. U.S.A. 93:14486-14491(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Caspase-10 is an initiator caspase in death receptor signaling."Proc. Natl. Acad. Sci. U.S.A. 98:13884-13888(2001) [PubMed] [Europe PMC] [Abstract]
  9. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth."Proc. Natl. Acad. Sci. U.S.A. 101:6170-6175(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II."Cell 98:47-58(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas."Blood 99:4094-4099(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Inactivating mutations of the caspase-10 gene in gastric cancer."Oncogene 21:2919-2925(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome."Hum. Genet. 119:284-294(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma."Hum. Mutat. 29:1443-1451(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Mutational analysis of CASP10 gene in acute leukaemias and multiple myelomas."Pathology 41:484-487(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Mutational analysis of CASP10 gene in colon, breast, lung and hepatocellular carcinomas."Pathology 42:73-76(2010) [PubMed] [Europe PMC] [Abstract]