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Nucleoporin 214kDa (NUP214)

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CAIN; CAN; N214; Nuclear Pore Complex Protein Nup214; CAN Protein,Putative Oncogene

Nucleoporin 214kDa (NUP214)
CCC B169
HGNC 8064
MGI 1095411
PubMed 16943420
RGD 1304977
UniProt P35658
Wiki NUP214

Nucleoporin 214kDa(NUP214;CAN),The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins.

The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleoporin 214kDa (NUP214) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleoporin 214kDa (NUP214) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleoporin 214kDa (NUP214) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleoporin 214kDa (NUP214) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoporin 214kDa (NUP214) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB169Mu01 Recombinant Nucleoporin 214kDa (NUP214) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB169Mu01 Polyclonal Antibody to Nucleoporin 214kDa (NUP214) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nucleoporin 214kDa (NUP214) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoporin 214kDa (NUP214) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleoporin 214kDa (NUP214) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleoporin 214kDa (NUP214) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleoporin 214kDa (NUP214) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleoporin 214kDa (NUP214) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoporin 214kDa (NUP214) ELISA Kit Customized Service Offer
  1. "The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA."Mol. Cell. Biol. 12:1687-1697(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm."Proc. Natl. Acad. Sci. U.S.A. 91:1519-1523(1994) [PubMed] [Europe PMC] [Abstract]
  6. "The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88."EMBO J. 16:807-816(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins."J. Cell Biol. 156:53-64(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Herpesvirus capsid association with the nuclear pore complex and viral DNA release involve the nucleoporin CAN/Nup214 and the capsid protein pUL25."J. Virol. 83:6610-6623(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN."Proc. Natl. Acad. Sci. U.S.A. 104:1783-1788(2007) [PubMed] [Europe PMC] [Abstract]
  22. "The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner."Nat. Struct. Mol. Biol. 16:247-254(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19."Proc. Natl. Acad. Sci. U.S.A. 106:3089-3094(2009) [PubMed] [Europe PMC] [Abstract]
  24. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]