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Cluster Of Differentiation 1d (CD1d)

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CD1-D; CD1A; R3G1; Antigen-presenting glycoprotein CD1d

Cluster Of Differentiation 1d (CD1d)
CCC B172
HGNC 1637
MGI 107674
PubMed 15146247
RGD 2296
UniProt P15813
Wiki CD1D
CD1d is a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T cells. It is the only member of the group 2 CD1 molecules. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail.CD1d presented lipid antigens activate a special class of T cells, known as Natural Killer T (NKT) cells. When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and IL-4 production.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB172Hu01 Recombinant Cluster Of Differentiation 1d (CD1d) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB172Hu01 Polyclonal Antibody to Cluster Of Differentiation 1d (CD1d) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 1d (CD1d) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 1d (CD1d) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB172Mu01 Recombinant Cluster Of Differentiation 1d (CD1d) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB172Mu01 Polyclonal Antibody to Cluster Of Differentiation 1d (CD1d) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 1d (CD1d) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 1d (CD1d) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB172Ra01 Recombinant Cluster Of Differentiation 1d (CD1d) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB172Ra01 Polyclonal Antibody to Cluster Of Differentiation 1d (CD1d) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 1d (CD1d) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 1d (CD1d) ELISA Kit Customized Service Offer
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  8. "Regulation of intracellular trafficking of human CD1d by association with MHC class II molecules."EMBO J. 21:1650-1660(2002) [PubMed] [Europe PMC] [Abstract]
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  10. "Distinct endosomal trafficking requirements for presentation of autoantigens and exogenous lipids by human CD1d molecules."J. Immunol. 178:6181-6190(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  12. "The crystal structure of human CD1d with and without alpha-galactosylceramide."Nat. Immunol. 6:819-826(2005) [PubMed] [Europe PMC] [Abstract]
  13. "CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor."Nature 448:44-49(2007) [PubMed] [Europe PMC] [Abstract]