≡

Cartilage Oligomeric Matrix Protein (COMP)

[Edit]

MED; EDM1; EPD1; PSACH; THBS5; TSP-5; Pseudoachondroplasia,Epiphyseal Dysplasia 1,Multiple; Thrombospondin 5

Cartilage Oligomeric Matrix Protein (COMP)
CCC B197
HGNC 2227
MGI 88469
PubMed 18855621
RGD 2378
UniProt P49747
Wiki COMP

Cartilage oligomeric matrix protein (COMP) is a member of the thrombospondin family of extracellular matrix proteins. The protein consists of five 87-kDa subunits held together by interchain disulfide bonds, forming a 435-kDa pentameric protein. COMP is expressed in all types of cartilage, vitreous of the eye, tendon, and vascular smooth muscle cells.

Immunohistological staining of articular cartilage has revealed a developmentally regulated localization of COMP to the chondrocyte territorial and interterritorial matrix. COMP binds in a zinc-dependent manner to collagen type I and type II and also to collagen type IX. The thrombospondin family currently includes five members: TSP-1, TSP-2, TSP-3, TSP-4, and COMP (also referred to as TSP-5).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB197Hu01 Recombinant Cartilage Oligomeric Matrix Protein (COMP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB197Hu01 Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB
MAB197Hu22 Monoclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB
MAB197Hu21 Monoclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB
Assay Kits SEB197Hu ELISA Kit for Cartilage Oligomeric Matrix Protein (COMP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB197Hu CLIA Kit for Cartilage Oligomeric Matrix Protein (COMP) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB197Mu01 Recombinant Cartilage Oligomeric Matrix Protein (COMP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB197Mu02 Recombinant Cartilage Oligomeric Matrix Protein (COMP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB197Mu03 Recombinant Cartilage Oligomeric Matrix Protein (COMP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB197Mu04 Recombinant Cartilage Oligomeric Matrix Protein (COMP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB197Mu01 Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC; IP.
PAB197Mu02 Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC; IP.
PAB197Mu04 Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC; IP.
PAB197Mu03 Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC; IP.
LAB197Mu71 Biotin-Linked Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC.
MAB197Mu21 Monoclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC; IP.
MAB197Mu22 Monoclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB.
Assay Kits SEB197Mu ELISA Kit for Cartilage Oligomeric Matrix Protein (COMP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB197Ra01 Recombinant Cartilage Oligomeric Matrix Protein (COMP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB197Ra02 Recombinant Cartilage Oligomeric Matrix Protein (COMP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB197Ra03 Recombinant Cartilage Oligomeric Matrix Protein (COMP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB197Ra01 Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC; IP.
PAB197Ra02 Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC; IP.
LAB197Ra71 Biotin-Linked Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC.
PAB197Ra03 Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC; IP.
Assay Kits SEB197Ra ELISA Kit for Cartilage Oligomeric Matrix Protein (COMP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB197Ra CLIA Kit for Cartilage Oligomeric Matrix Protein (COMP) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cartilage Oligomeric Matrix Protein (COMP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) Polyclonal Antibody Customized Service Offer
Assay Kits SEB197Ca ELISA Kit for Cartilage Oligomeric Matrix Protein (COMP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cartilage Oligomeric Matrix Protein (COMP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cartilage Oligomeric Matrix Protein (COMP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cartilage Oligomeric Matrix Protein (COMP) ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cartilage Oligomeric Matrix Protein (COMP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) Polyclonal Antibody Customized Service Offer
Assay Kits SEB197Eq ELISA Kit for Cartilage Oligomeric Matrix Protein (COMP) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Characterization of human and mouse cartilage oligomeric matrix protein."Genomics 24:435-439(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene."Nat. Genet. 10:330-336(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Cartilage oligomeric matrix protein is a calcium-binding protein, and a mutation in its type 3 repeats causes conformational changes."J. Biol. Chem. 275:26538-26544(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II, and IX."J. Biol. Chem. 276:6083-6092(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin."Matrix Biol. 21:461-470(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias."J. Biol. Chem. 279:25294-25298(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins."J. Biol. Chem. 280:32655-32661(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis."Arthritis Res. Ther. 8:R56-R56(2006) [PubMed] [Europe PMC] [Abstract]
  12. "ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein."J. Biol. Chem. 281:15800-15808(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan."J. Biol. Chem. 282:24591-24598(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins."J. Biol. Chem. 283:648-659(2008) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding."FASEB J. 23:2490-2501(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia."Nat. Genet. 10:325-329(1995) [PubMed] [Europe PMC] [Abstract]
  18. "Multiple epiphyseal dysplasia, ribbing type: a novel point mutation in the COMP gene in a South African family."Am. J. Med. Genet. 68:396-400(1997) [PubMed] [Europe PMC] [Abstract]
  19. "Multiple epiphyseal dysplasia and pseudoachondroplasia due to novel mutations in the calmodulin-like repeats of cartilage oligomeric matrix protein."Clin. Genet. 51:219-224(1997) [PubMed] [Europe PMC] [Abstract]
  20. "Diverse mutations in the gene for cartilage oligomeric matrix protein in the pseudoachondroplasia-multiple epiphyseal dysplasia disease spectrum."Am. J. Hum. Genet. 62:311-319(1998) [PubMed] [Europe PMC] [Abstract]
  21. "Novel and recurrent COMP (cartilage oligomeric matrix protein) mutations in pseudoachondroplasia and multiple epiphyseal dysplasia."Hum. Genet. 103:633-638(1998) [PubMed] [Europe PMC] [Abstract]
  22. "Identification of five novel mutations in cartilage oligomeric matrix protein gene in pseudoachondroplasia and multiple epiphyseal dysplasia."Hum. Mutat. Suppl. 1:S10-S17(1998) [PubMed] [Europe PMC] [Abstract]
  23. "Pseudoachondroplasia due to the substitution of the highly conserved Asp482 by Gly in the seventh calmodulin-like repeat of cartilage oligomeric matrix protein."Hum. Mutat. Suppl. 1:S125-S127(1998) [PubMed] [Europe PMC] [Abstract]
  24. "Double heterozygosity for pseudoachondroplasia and spondyloepiphyseal dysplasia congenita."Am. J. Med. Genet. 104:140-146(2001) [PubMed] [Europe PMC] [Abstract]
  25. "Novel mutation in exon 18 of the cartilage oligomeric matrix protein gene causes a severe pseudoachondroplasia."Am. J. Med. Genet. 104:135-139(2001) [PubMed] [Europe PMC] [Abstract]
  26. "A mutation in COL9A1 causes multiple epiphyseal dysplasia: further evidence for locus heterogeneity."Am. J. Hum. Genet. 69:969-980(2001) [PubMed] [Europe PMC] [Abstract]
  27. "Pseudoachondroplasia and multiple epiphyseal dysplasia: A 7-year comprehensive analysis of the known disease genes identify novel and recurrent mutations and provides an accurate assessment of their relative contribution."Hum. Mutat. 33:144-157(2012) [PubMed] [Europe PMC] [Abstract]