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Zinc Finger Homeobox Protein 3 (ZFHX3)

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ATBF1; ATBT; AT-Binding Transcription Factor 1; AT-Motif-Binding Factor 1; Alpha-Fetoprotein Enhancer-Binding Protein

Zinc Finger Homeobox Protein 3 (ZFHX3)
CCC B199
HGNC 777
MGI 99948
PubMed 19597492
RGD 1560268
UniProt Q15911
Wiki ZFHX3

Tissue-specific expression of the human alpha-fetoprotein (AFP) gene is strongly stimulated by an enhancer present 3.3 to 4.9 kb upstream of the transcription initiation site.  To determine the nuclear factor in hepatoma cell lines that interacts with the human AFP enhancer AT motif, Morinaga et al. (1991) screened a hepatoma cDNA expression library with an AFP enhancer fragment that bore the AT motif. They succeeded in isolating a cDNA that can code for an AT motif-binding factor, which they termed ATBF1. This was the largest DNA-binding protein identified to that time and the first protein shown to contain multiple homeodomains and multiple zinc finger motifs. The protein had a predicted mass of 306 kD and contained 4 homeodomains and 17 zinc finger motifs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Homeobox Protein 3 (ZFHX3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Homeobox Protein 3 (ZFHX3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Homeobox Protein 3 (ZFHX3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Homeobox Protein 3 (ZFHX3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Homeobox Protein 3 (ZFHX3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Homeobox Protein 3 (ZFHX3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Homeobox Protein 3 (ZFHX3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Homeobox Protein 3 (ZFHX3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Homeobox Protein 3 (ZFHX3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Homeobox Protein 3 (ZFHX3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Homeobox Protein 3 (ZFHX3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Homeobox Protein 3 (ZFHX3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Homeobox Protein 3 (ZFHX3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Homeobox Protein 3 (ZFHX3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Homeobox Protein 3 (ZFHX3) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner."J. Biol. Chem. 270:26840-26848(1995) [PubMed] [Europe PMC] [Abstract]
  2. "A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers."Mol. Cell. Biol. 11:6041-6049(1991) [PubMed] [Europe PMC] [Abstract]
  3. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1."J. Biol. Chem. 276:25057-25065(2001) [PubMed] [Europe PMC] [Abstract]
  6. "ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3."Biochem. Biophys. Res. Commun. 314:97-103(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer."Int. J. Cancer 121:241-247(2007) [PubMed] [Europe PMC] [Abstract]
  9. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke." Nat. Genet. 41:876-878(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry." Nat. Genet. 41:879-881(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Human ALKBH4 interacts with proteins associated with transcription."PLoS ONE 7:E49045-E49045(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Solution structure of the second and third homeobox domain of AT-binding transcription factor 1 (ATBF1)."Submitted (JUN-2006) to the PDB data bank