≡

Contactin 4 (CNTN4)

[Edit]

AXCAM; BIG-2; CNTN4A; Brain-derived immunoglobulin superfamily protein 2

Contactin 4 (CNTN4)
CCC B210
HGNC 2174
MGI 1095737
PubMed 18551756
RGD 621361
UniProt Q8IWV2
Wiki CNTN4

Contactin-4 is a  member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

The gene is located on the short arm of chromosome 3 (3p26.3). It is a single copy gene within the Watson (plus) strand, 957,399 bases in length and encodes a protein of 1026 amino acids (molecular weight 113.454 kDa)Abnormal expression of this gene has been implicated in some cases of autism.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB210Hu01 Recombinant Contactin 4 (CNTN4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB210Hu01 Polyclonal Antibody to Contactin 4 (CNTN4) WB,IHC
MAB210Hu21 Monoclonal Antibody to Contactin 4 (CNTN4) WB; IHC; ICC; IP.
Assay Kits SEB210Hu ELISA Kit for Contactin 4 (CNTN4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Contactin 4 (CNTN4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Contactin 4 (CNTN4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Contactin 4 (CNTN4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Contactin 4 (CNTN4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Contactin 4 (CNTN4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Contactin 4 (CNTN4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Contactin 4 (CNTN4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Contactin 4 (CNTN4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Contactin 4 (CNTN4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Contactin 4 (CNTN4) ELISA Kit Customized Service Offer
  1. "A novel splice variant of the cell adhesion molecule contactin 4 (CNTN4) is mainly expressed in human brain."J. Hum. Genet. 47:497-499(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of the human neural cell adhesion molecule, CNTN4 (alias BIG-2)."Cytogenet. Genome Res. 101:17-23(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members."Genomics 69:113-119(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Disruption of contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome."Am. J. Hum. Genet. 74:1286-1293(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules."Proc. Natl. Acad. Sci. U.S.A. 107:2443-2448(2010) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]