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Retinoblastoma Protein 1 (RB1)

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OSRC; PRB; p105-Rb; pp110; Including Osteosarcoma; Retinoblastoma-associated protein

Retinoblastoma Protein 1 (RB1)
CCC B211
HGNC 9884
MGI 97874
PubMed 8384581
RGD 3540
UniProt P06400
Wiki RB1

The retinoblastoma protein (abbreviated pRb or Rb) is a tumor suppressor protein that is dysfunctional in many types of cancer. One highly studied function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins. Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomaviruses, bind and inactivate pRb, this can lead to cancer.

In humans, the protein is encoded by the RB1 gene located on 13q14.1-q14.2. If both alleles of this gene are mutated early in life, the protein is inactivated and results in development of retinoblastoma cancer, hence the name Rb.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB211Hu01 Recombinant Retinoblastoma Protein 1 (RB1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB211Hu02 Recombinant Retinoblastoma Protein 1 (RB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB211Hu01 Polyclonal Antibody to Retinoblastoma Protein 1 (RB1) WB; IHC; ICC; IP.
PAB211Hu02 Polyclonal Antibody to Retinoblastoma Protein 1 (RB1) WB; IHC; ICC; IP.
LAB211Hu71 Biotin-Linked Polyclonal Antibody to Retinoblastoma Protein 1 (RB1) WB; IHC; ICC.
Assay Kits SEB211Hu ELISA Kit for Retinoblastoma Protein 1 (RB1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Protein 1 (RB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Protein 1 (RB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Protein 1 (RB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Protein 1 (RB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Protein 1 (RB1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Protein 1 (RB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Protein 1 (RB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Protein 1 (RB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Protein 1 (RB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Protein 1 (RB1) ELISA Kit Customized Service Offer
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