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Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4)

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CD152; CELIAC3; CTLA4; GSE; IDDM12; Celiac Disease 3; Cytotoxic T-lymphocyte protein 4

Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4)
CCC B230
HGNC 2505
MGI 88556
PubMed 15790353
RGD 61975
UniProt P16410
Wiki CTLA-4

CTLA4 is a protein that plays an important regulatory role in the immune system. In humans, the CTLA4 protein is encoded by the CTLA4 gene.CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells.

CTLA4 is similar to the T-cell costimulatory protein CD28, and both molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA-4, an inhibitory receptor for B7 molecules.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB230Hu01 Recombinant Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) Positive Control; Immunogen; SDS-PAGE; WB.
RPB230Hu02 Recombinant Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) Positive Control; Immunogen; SDS-PAGE; WB.
RPB230Hu03 Recombinant Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) Positive Control; Immunogen; SDS-PAGE; WB.
RPB230Hu04 Recombinant Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB230Hu01 Polyclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) WB; IHC; ICC; IP.
MAB230Hu22 Monoclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) WB; IHC; ICC; IP.
MAB230Hu21 Monoclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) WB.
MAB230Hu23 Monoclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) WB; IHC; ICC; IP.
PAB230Hu02 Polyclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) WB; IHC; ICC; IP.
MAB230Hu24 Monoclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) WB; IHC; ICC; IP.
MAB230Hu25 Monoclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) WB; IHC; ICC; IP.
MAB230Hu26 Monoclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) WB; IHC; ICC; IP.
MAB230Hu27 Monoclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) WB; IHC; ICC; IP.
MAB230Hu28 Monoclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) WB; IHC; ICC; IP.
MAB230Hu29 Monoclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) WB; IHC; ICC; IP.
Assay Kits SEB230Hu ELISA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB230Mu01 Recombinant Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) Positive Control; Immunogen; SDS-PAGE; WB.
RPB230Mu02 Recombinant Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB230Mu01 Polyclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB230Ra01 Recombinant Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB230Ra01 Polyclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) ELISA Kit Customized Service Offer
  1. "CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location."J. Immunol. 147:1037-1044(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches."Genomics 78:155-168(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of CTLA-4 isoforms produced by alternative splicing and their association with myasthenia gravis."Clin. Immunol. 128:374-381(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains."Eur. J. Immunol. 18:1901-1905(1988) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders."Genomics 60:341-355(1999) [PubMed] [Europe PMC] [Abstract]
  8. "CTLA-4 is a second receptor for the B cell activation antigen B7."J. Exp. Med. 174:561-569(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2."Immunity 6:583-589(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4."Biochem. Biophys. Res. Commun. 252:14-19(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4."J. Cell. Biochem. 78:241-250(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease." Nature 423:506-511(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Hierarchical regulation of CTLA-4 dimer-based lattice formation and its biological relevance for T cell inactivation."J. Immunol. 175:996-1004(2005) [PubMed] [Europe PMC] [Abstract]
  14. "A molecular perspective of CTLA-4 function."Annu. Rev. Immunol. 24:65-97(2006) [PubMed] [Europe PMC] [Abstract]
  15. "CTLA-4 trafficking and surface expression."Trends Immunol. 29:272-279(2008) [PubMed] [Europe PMC] [Abstract]
  16. "The clinical utility of inhibiting CD28-mediated costimulation."Immunol. Rev. 229:307-321(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28."Nat. Struct. Biol. 4:527-531(1997) [PubMed] [Europe PMC] [Abstract]
  18. "Structural basis for co-stimulation by the human CTLA-4/B7-2 complex."Nature 410:604-608(2001) [PubMed] [Europe PMC] [Abstract]
  19. "Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses."Nature 410:608-611(2001) [PubMed] [Europe PMC] [Abstract]
  20. "Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering."J. Biol. Chem. 286:6685-6696(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups." Hum. Mol. Genet. 6:1275-1282(1997) [PubMed] [Europe PMC] [Abstract]
  22. "CTLA-4 gene polymorphism is associated with predisposition to coeliac disease."Gut 43:187-189(1998) [PubMed] [Europe PMC] [Abstract]
  23. "Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy."Lancet 354:743-744(1999) [PubMed] [Europe PMC] [Abstract]
  24. "Complex association analysis of Graves disease using a set of polymorphic markers."Mol. Genet. Metab. 70:214-218(2000) [PubMed] [Europe PMC] [Abstract]
  25. "Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene."Am. J. Hum. Genet. 67:737-744(2000) [PubMed] [Europe PMC] [Abstract]
  26. "Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus."Eur. J. Hum. Genet. 12:620-626(2004) [PubMed] [Europe PMC] [Abstract]
  27. "Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection."J. Virol. 78:11258-11262(2004) [PubMed] [Europe PMC] [Abstract]
  28. "A common CTLA4 haplotype associated with coeliac disease."Eur. J. Hum. Genet. 13:440-444(2005) [PubMed] [Europe PMC] [Abstract]
  29. "CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis."Hum. Genet. 116:361-367(2005) [PubMed] [Europe PMC] [Abstract]
  30. "Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations." Nat. Med. 20:1410-1416(2014) [PubMed] [Europe PMC] [Abstract]
  31. "Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4." Science 345:1623-1627(2014) [PubMed] [Europe PMC] [Abstract]