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Cyclin Dependent Kinase 4 (CDK4)

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CMM3; PSK-J3; Cell division protein kinase 4

Cyclin Dependent Kinase 4 (CDK4)
CCC B233
HGNC 1773
MGI 88357
PubMed 24089445
RGD 621120
UniProt P11802
Wiki CDK4

Cyclin-dependent kinase 4 is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.It is regulated by Cyclin D.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB233Hu01 Recombinant Cyclin Dependent Kinase 4 (CDK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB233Hu01 Polyclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB,IHC
MAB233Hu22 Monoclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IP.
Assay Kits SEB233Hu ELISA Kit for Cyclin Dependent Kinase 4 (CDK4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB233Mu01 Recombinant Cyclin Dependent Kinase 4 (CDK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB233Mu01 Polyclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IP.
LAB233Mu81 FITC-Linked Polyclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IF.
LAB233Mu71 Biotin-Linked Polyclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Cyclin Dependent Kinase 4 (CDK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Dependent Kinase 4 (CDK4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin Dependent Kinase 4 (CDK4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin Dependent Kinase 4 (CDK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Dependent Kinase 4 (CDK4) ELISA Kit Customized Service Offer
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  2. "A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma."Science 269:1281-1284(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma."Nat. Genet. 12:97-99(1996) [PubMed] [Europe PMC] [Abstract]
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  8. "Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas."Cancer Res. 53:5535-5541(1993) [PubMed] [Europe PMC] [Abstract]
  9. "The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2."EMBO J. 15:7060-7069(1996) [PubMed] [Europe PMC] [Abstract]
  10. "New functional activities for the p21 family of CDK inhibitors."Genes Dev. 11:847-862(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1)."Genes Dev. 13:3027-3033(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity."Genes Dev. 18:912-925(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Cyclin-dependent kinases regulate the antiproliferative function of Smads."Nature 430:226-231(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Characterization of VIK-1: a new Vav-interacting Kruppel-like protein."Oncogene 24:28-38(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'."Mol. Cell. Biol. 26:5070-5085(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition."Cell Struct. Funct. 33:171-183(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest."J. Biol. Chem. 284:5574-5581(2009) [PubMed] [Europe PMC] [Abstract]
  19. "p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes."Mol. Cell. Biol. 29:986-999(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation."Mol. Cell. Biol. 29:4188-4200(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Crystal structure of human CDK4 in complex with a D-type cyclin."Proc. Natl. Acad. Sci. U.S.A. 106:4166-4170(2009) [PubMed] [Europe PMC] [Abstract]
  24. "The structure of CDK4/cyclin D3 has implications for models of CDK activation."Proc. Natl. Acad. Sci. U.S.A. 106:4171-4176(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Complete scanning of the CDK4 gene by denaturing gradient gel electrophoresis: a novel missense mutation but low overall frequency of mutations in sporadic metastatic malignant melanoma."Int. J. Cancer 72:780-783(1997) [PubMed] [Europe PMC] [Abstract]
  26. "Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France."Hum. Mol. Genet. 7:209-216(1998) [PubMed] [Europe PMC] [Abstract]
  27. ErratumHum. Mol. Genet. 7:941-941(1998)
  28. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]