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Androgen Receptor (AR)

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AIS; DHTR; HUMARA; KD; NR3C4; SBMA; SMAX1; TFM; Dihydrotestosterone receptor; Nuclear Receptor Subfamily 3,Group C,Member 4; Testicular Feminization; Kennedy Disease

Androgen Receptor (AR)
CCC B252
HGNC 644
MGI 88064
PubMed 15082523
RGD 2147
UniProt P10275
Wiki AR
The androgen receptor (AR) is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB252Hu01 Recombinant Androgen Receptor (AR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB252Hu03 Recombinant Androgen Receptor (AR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB252Hu02 Recombinant Androgen Receptor (AR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB252Hu01 Polyclonal Antibody to Androgen Receptor (AR) WB; IHC; ICC; IP.
MAB252Hu22 Monoclonal Antibody to Androgen Receptor (AR) WB; IHC; ICC; IP.
LAB252Hu71 Biotin-Linked Polyclonal Antibody to Androgen Receptor (AR) WB; IHC; ICC.
PAB252Hu02 Polyclonal Antibody to Androgen Receptor (AR) WB; IHC; ICC; IP.
Assay Kits SEB252Hu ELISA Kit for Androgen Receptor (AR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB252Mu01 Recombinant Androgen Receptor (AR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB252Mu02 Recombinant Androgen Receptor (AR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB252Mu01 Polyclonal Antibody to Androgen Receptor (AR) WB; IHC; ICC; IP.
PAB252Mu02 Polyclonal Antibody to Androgen Receptor (AR) WB; IHC; ICC; IP.
Assay Kits SEB252Mu ELISA Kit for Androgen Receptor (AR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB252Ra01 Recombinant Androgen Receptor (AR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB252Ra02 Recombinant Androgen Receptor (AR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB252Ra01 Polyclonal Antibody to Androgen Receptor (AR) WB; IHC; ICC; IP.
PAB252Ra02 Polyclonal Antibody to Androgen Receptor (AR) WB; IHC; ICC; IP.
LAB252Ra71 Biotin-Linked Polyclonal Antibody to Androgen Receptor (AR) WB; IHC; ICC.
MAB252Ra21 Monoclonal Antibody to Androgen Receptor (AR) WB; IHC; ICC; IP.
MAB252Ra22 Monoclonal Antibody to Androgen Receptor (AR) WB; IHC; ICC; IP.
MAB252Ra23 Monoclonal Antibody to Androgen Receptor (AR) WB; IHC; ICC; IP.
Assay Kits SEB252Ra ELISA Kit for Androgen Receptor (AR) Enzyme-linked immunosorbent assay for Antigen Detection.
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  49. "CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation."Mol. Endocrinol. 24:2267-2280(2010) [PubMed] [Europe PMC] [Abstract]
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  108. "Microsatellite mutation (CAG24-->18) in the androgen receptor gene in human prostate cancer."Biochem. Biophys. Res. Commun. 198:74-80(1994) [PubMed] [Europe PMC] [Abstract]
  109. "Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers."Cancer Res. 54:2861-2864(1994) [PubMed] [Europe PMC] [Abstract]
  110. "Molecular prenatal diagnosis of partial androgen insensitivity syndrome based on the Hind III polymorphism of the androgen receptor gene."Clin. Endocrinol. (Oxf.) 40:297-302(1994) [PubMed] [Europe PMC] [Abstract]
  111. "Molecular prenatal exclusion of familial partial androgen insensitivity (Reifenstein syndrome)."Eur. J. Endocrinol. 130:327-332(1994) [PubMed] [Europe PMC] [Abstract]
  112. "Single amino acid substitution (840Arg-->His) in the hormone-binding domain of the androgen receptor leads to incomplete androgen insensitivity syndrome associated with a thermolabile androgen receptor."Eur. J. Endocrinol. 130:569-574(1994) [PubMed] [Europe PMC] [Abstract]
  113. "Molecular characterization of the androgen receptor gene in boys with hypospadias."Eur. J. Pediatr.