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Prolylcarboxypeptidase (PRCP)

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PCP; HUMPCP; Lysosomal Pro-X Carboxypeptidase; Angiotensinase C; Lysosomal carboxypeptidase C; Proline carboxypeptidase

Prolylcarboxypeptidase (PRCP)
CCC B253
HGNC 9344
MGI 1919711
PubMed 23744584
RGD 1307842
UniProt P42785
Wiki PRCP
Lysosomal Pro-X carboxypeptidase is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein.
The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB253Hu01 Recombinant Prolylcarboxypeptidase (PRCP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB253Hu01 Polyclonal Antibody to Prolylcarboxypeptidase (PRCP) WB,IHC
MAB253Hu21 Monoclonal Antibody to Prolylcarboxypeptidase (PRCP) WB; IHC; ICC; IP.
Assay Kits SEB253Hu ELISA Kit for Prolylcarboxypeptidase (PRCP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB253Mu01 Recombinant Prolylcarboxypeptidase (PRCP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB253Mu01 Polyclonal Antibody to Prolylcarboxypeptidase (PRCP) WB,IHC
Assay Kits n/a CLIA Kit for Prolylcarboxypeptidase (PRCP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prolylcarboxypeptidase (PRCP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB253Ra01 Recombinant Prolylcarboxypeptidase (PRCP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB253Ra01 Polyclonal Antibody to Prolylcarboxypeptidase (PRCP) WB; IHC; ICC; IP.
MAB253Ra21 Monoclonal Antibody to Prolylcarboxypeptidase (PRCP) WB; IHC; ICC; IP.
Assay Kits SEB253Ra ELISA Kit for Prolylcarboxypeptidase (PRCP) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families."J. Biol. Chem. 268:16631-16638(1993) [PubMed] [Europe PMC] [Abstract]
  2. ErratumJ. Biol. Chem. 268:26032-26032(1993)
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Purification and properties of prolylcarboxypeptidase (angiotensinase C) from human kidney."J. Biol. Chem. 253:5927-5931(1978) [PubMed] [Europe PMC] [Abstract]
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase."BMC Struct. Biol. 10:16-16(2010) [PubMed] [Europe PMC] [Abstract]