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Cathepsin D (CTSD)

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CPSD; CLN10; Lysosomal Aspartyl Protease; Ceroid-Lipofuscinosis,Neuronal 10

Cathepsin D (CTSD)
CCC B280
HGNC 2529
MGI 88562
PubMed 19919557
RGD 621511
UniProt P07339
Wiki Cathepsin_D
Cathepsin D, is a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.
Faust et al. (1985) cloned human cathepsin D from a kidney cDNA library. The cDNA encodes a 412-amino acid protein with 20 and 44 amino acids in a pre- and prosegment, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB280Hu01 Recombinant Cathepsin D (CTSD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB280Hu02 Recombinant Cathepsin D (CTSD) Positive Control; Immunogen; SDS-PAGE; WB.
APB280Hu61 Active Cathepsin D (CTSD) Cell culture; Activity Assays.
EPB280Hu61 Eukaryotic Cathepsin D (CTSD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB280Hu03 Recombinant Cathepsin D (CTSD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB280Hu04 Recombinant Cathepsin D (CTSD) Positive Control; Immunogen; SDS-PAGE; WB.
EPB280Hu62 Eukaryotic Cathepsin D (CTSD) Positive Control; Immunogen; SDS-PAGE; WB.
APB280Hu62 Active Cathepsin D (CTSD) Cell culture; Activity Assays.
Antibodies PAB280Hu01 Polyclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC; IP.
MAB280Hu22 Monoclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC; IP.
PAB280Hu02 Polyclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC; IP.
LAB280Hu71 Biotin-Linked Polyclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC.
MAB280Hu21 Monoclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC; IP.
MAB280Hu26 Monoclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC; IP.
Assay Kits SEB280Hu ELISA Kit for Cathepsin D (CTSD) Enzyme-linked immunosorbent assay for Antigen Detection.
HEB280Hu High Sensitive ELISA Kit for Cathepsin D (CTSD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB280Mu01 Recombinant Cathepsin D (CTSD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB280Mu02 Recombinant Cathepsin D (CTSD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB280Mu01 Polyclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC; IP.
PAB280Mu02 Polyclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC; IP.
Assay Kits SEB280Mu ELISA Kit for Cathepsin D (CTSD) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB280Mu CLIA Kit for Cathepsin D (CTSD) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB280Ra01 Recombinant Cathepsin D (CTSD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB280Ra02 Recombinant Cathepsin D (CTSD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB280Ra03 Recombinant Cathepsin D (CTSD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB280Ra01 Polyclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC; IP.
PAB280Ra02 Polyclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC; IP.
PAB280Ra03 Polyclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC; IP.
Assay Kits SEB280Ra ELISA Kit for Cathepsin D (CTSD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB280Bo01 Recombinant Cathepsin D (CTSD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB280Bo01 Polyclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC; IP.
MAB280Bo21 Monoclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC; IP.
Assay Kits CEB280Bo ELISA Kit for Cathepsin D (CTSD) Enzyme-linked immunosorbent assay for Antigen Detection.
SEB280Bo ELISA Kit for Cathepsin D (CTSD) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning and sequence analysis of cDNA for human cathepsin D."Proc. Natl. Acad. Sci. U.S.A. 82:4910-4914(1985) [PubMed] [Europe PMC] [Abstract]
  2. "Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells."Nucleic Acids Res. 15:3773-3786(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular organization of the human cathepsin D gene."DNA Cell Biol. 10:423-431(1991) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The human cathepsin D-encoding gene is transcribed from an estrogen-regulated and a constitutive start point."Gene 134:277-282(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of the proximal estrogen-responsive element of human cathepsin D gene."Mol. Endocrinol. 8:693-703(1994) [PubMed] [Europe PMC] [Abstract]
  7. , Submitted (JUN-1992) to UniProtKB
  8. "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."J. Proteome Res. 2:69-79(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis."Brain 129:1438-1445(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Proteomics characterization of extracellular space components in the human aorta."Mol. Cell. Proteomics 9:2048-2062(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Two crystal structures for cathepsin D: the lysosomal targeting signal and active site."EMBO J. 12:1293-1302(1993) [PubMed] [Europe PMC] [Abstract]
  20. "Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design."Proc. Natl. Acad. Sci. U.S.A. 90:6796-6800(1993) [PubMed] [Europe PMC] [Abstract]
  21. "A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease."Ann. Neurol. 47:399-403(2000) [PubMed] [Europe PMC] [Abstract]
  22. "Cathepsin D deficiency is associated with a human neurodegenerative disorder."Am. J. Hum. Genet. 78:988-998(2006) [PubMed] [Europe PMC] [Abstract]
  23. "Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses."Hum. Mutat. 33:42-63(2012) [PubMed] [Europe PMC] [Abstract]