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Integrin Alpha 5 (ITGa5)

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CD49e; CD49-E; ITG-A5; FNRA; VLA5A; Fibronectin Receptor,Alpha Polypeptide; Integrin alpha-F; CD49 antigen-like family member E

Integrin Alpha 5 (ITGa5)
CCC B287
HGNC 6141
MGI 96604
PubMed 23686445
RGD 2925
UniProt P08648
Wiki ITGA5
Integrin alpha-5 is product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.Argraves et al. (1986) isolated cDNA clones coding for the alpha subunit from a placenta cDNA library. The cDNAs code for 229 amino acids from the C terminus of the alpha subunit. The deduced sequence has a hydrophobic region with properties characteristic of a membrane-spanning domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB287Hu01 Recombinant Integrin Alpha 5 (ITGa5) Positive Control; Immunogen; SDS-PAGE; WB.
RPB287Hu02 Recombinant Integrin Alpha 5 (ITGa5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB287Hu01 Polyclonal Antibody to Integrin Alpha 5 (ITGa5) WB; IHC; ICC; IP.
MAB287Hu22 Monoclonal Antibody to Integrin Alpha 5 (ITGa5) WB; IHC; ICC; IP.
Assay Kits SEB287Hu ELISA Kit for Integrin Alpha 5 (ITGa5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB287Mu01 Recombinant Integrin Alpha 5 (ITGa5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB287Mu01 Polyclonal Antibody to Integrin Alpha 5 (ITGa5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Integrin Alpha 5 (ITGa5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Alpha 5 (ITGa5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB287Ra01 Recombinant Integrin Alpha 5 (ITGa5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB287Ra01 Polyclonal Antibody to Integrin Alpha 5 (ITGa5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Integrin Alpha 5 (ITGa5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Alpha 5 (ITGa5) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB287Bo01 Recombinant Integrin Alpha 5 (ITGa5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB287Bo01 Polyclonal Antibody to Integrin Alpha 5 (ITGa5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Integrin Alpha 5 (ITGa5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Alpha 5 (ITGa5) ELISA Kit Customized Service Offer
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  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  4. "Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb."Biochemistry 26:8158-8165(1987) [PubMed] [Europe PMC] [Abstract]
  5. "cDNA sequences from the alpha subunit of the fibronectin receptor predict a transmembrane domain and a short cytoplasmic peptide."J. Biol. Chem. 261:12922-12924(1986) [PubMed] [Europe PMC] [Abstract]
  6. "The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis."Proc. Natl. Acad. Sci. U.S.A. 84:3239-3243(1987) [PubMed] [Europe PMC] [Abstract]
  7. "The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor."Blood 94:663-672(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Insulin receptor substrate 4 associates with the protein IRAS."J. Biol. Chem. 277:19439-19447(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Mass spectrometric based mapping of the disulfide bonding patterns of integrin alpha chains."Biochemistry 42:12950-12959(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins."J. Biol. Chem. 280:32655-32661(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins."J. Cell Biol. 173:767-780(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Cleavage of endometrial alpha-integrins into their functional forms is mediated by proprotein convertase 5/6."Hum. Reprod. 27:2766-2774(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity."Biochemistry 52:7082-7090(2013) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Crystal structure of alpha5beta1 integrin ectodomain: atomic details of the fibronectin receptor."J. Cell Biol. 197:131-140(2012) [PubMed] [Europe PMC] [Abstract]